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• W2951287641 abstract "An efficient solution-phase parallel synthesis of a library of 3,5,7-trisubstituted [1,2,3]triazolo[4,5-d]pyrimidines is described. Monosubstituted amidines may be converted to 2-substituted 5-amino-4,6-dihydroxypyrimidines in four steps. Treatment with a primary amine followed by cyclization yields the 7-chloro-3,5-disubstituted [1,2,3]triazolo[4,5-d]pyrimidines as penultimate intermediates. Final nucleophilic substitution of the 7-chloro group with an excess of a primary or secondary amine, a hydrazine or a O-alkylhydroxylamine proceeds efficiently. Scavenging of the excess amine with a resin-bound isocyanate in the presence of resin-bound piperidine as a base affords the desired 3,5,7-trisubstituted [1,2,3]triazolo[4,5-d]pyrimidines in good yields and purities." @default.
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• W2951287641 date "2003-07-18" @default.
• W2951287641 modified "2023-10-16" @default.
• W2951287641 title "Solution-Phase Synthesis of a Library of 3,5,7-Trisubstituted 3<i>H</i>-[1,2,3]triazolo[4,5-<i>d</i>]pyrimidines" @default.
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• W2951287641 doi "https://doi.org/10.1021/cc020110x" @default.
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