FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951320675> ?p ?o ?g. }

• W2951320675 endingPage "794" @default.
• W2951320675 startingPage "781" @default.
• W2951320675 abstract "Abstract Background Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk. Methods Summary-level genotype data from 23andMe, Inc (breast size, n = 33 790), the Breast Cancer Association Consortium (breast cancer risk, n = 228 951) and the Genetic Investigation of ANthropometric Traits (BMI, n = 183 507) were used for our analyses. In assessing causal relationships, four complementary MR techniques [inverse variance weighted (IVW), weighted median, weighted mode and MR-Egger regression] were used to test the robustness of the results. Results The genetic correlation (rg) estimated between BMI and breast size was high (rg = 0.50, P = 3.89x10−43). All MR methods provided consistent evidence that higher genetically predicted BMI was associated with larger breast size [odds ratio (ORIVW): 2.06 (1.80–2.35), P = 1.38x10−26] and lower overall breast cancer risk [ORIVW: 0.81 (0.74–0.89), P = 9.44x10−6]. No evidence of a relationship between genetically predicted breast size and breast cancer risk was found except when using the weighted median and weighted mode methods, and only with oestrogen receptor (ER)-negative risk. There was no evidence of reverse causality in any of the analyses conducted (P > 0.050). Conclusion Our findings indicate a potential positive causal association between BMI and breast size and a potential negative causal association between BMI and breast cancer risk. We found no clear evidence for a direct relationship between breast size and breast cancer risk." @default.
• W2951320675 created "2019-06-27" @default.
• W2951320675 creator A5007991040 @default.
• W2951320675 creator A5013699285 @default.
• W2951320675 creator A5017728105 @default.
• W2951320675 creator A5018786162 @default.
• W2951320675 creator A5019133187 @default.
• W2951320675 creator A5019844612 @default.
• W2951320675 creator A5025137857 @default.
• W2951320675 creator A5026611118 @default.
• W2951320675 creator A5038891840 @default.
• W2951320675 creator A5040523850 @default.
• W2951320675 creator A5040540995 @default.
• W2951320675 creator A5040933938 @default.
• W2951320675 creator A5049055281 @default.
• W2951320675 creator A5050097355 @default.
• W2951320675 creator A5052267876 @default.
• W2951320675 creator A5053177403 @default.
• W2951320675 creator A5056487867 @default.
• W2951320675 creator A5061244591 @default.
• W2951320675 creator A5063459619 @default.
• W2951320675 creator A5063650101 @default.
• W2951320675 creator A5072047782 @default.
• W2951320675 creator A5077206620 @default.
• W2951320675 creator A5084633297 @default.
• W2951320675 creator A5087003938 @default.
• W2951320675 date "2019-06-01" @default.
• W2951320675 modified "2023-10-14" @default.
• W2951320675 title "The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis" @default.
• W2951320675 cites W1492426709 @default.
• W2951320675 cites W1905058580 @default.
• W2951320675 cites W2002715948 @default.
• W2951320675 cites W2008021904 @default.
• W2951320675 cites W2010927762 @default.
• W2951320675 cites W2011118151 @default.
• W2951320675 cites W2023585052 @default.
• W2951320675 cites W2039153962 @default.
• W2951320675 cites W2042328371 @default.
• W2951320675 cites W2054464467 @default.
• W2951320675 cites W2055576561 @default.
• W2951320675 cites W2057064709 @default.
• W2951320675 cites W2085003501 @default.
• W2951320675 cites W2103212781 @default.
• W2951320675 cites W2113699335 @default.
• W2951320675 cites W2128472512 @default.
• W2951320675 cites W2131944330 @default.
• W2951320675 cites W2135665336 @default.
• W2951320675 cites W2141937355 @default.
• W2951320675 cites W2153383900 @default.
• W2951320675 cites W2155226662 @default.
• W2951320675 cites W2160408484 @default.
• W2951320675 cites W2160596573 @default.
• W2951320675 cites W2195783463 @default.
• W2951320675 cites W2324862792 @default.
• W2951320675 cites W2401811918 @default.
• W2951320675 cites W2483210912 @default.
• W2951320675 cites W2514982885 @default.
• W2951320675 cites W2613603864 @default.
• W2951320675 cites W2620230414 @default.
• W2951320675 cites W2625977525 @default.
• W2951320675 cites W2765253743 @default.
• W2951320675 cites W2782929519 @default.
• W2951320675 cites W2782947867 @default.
• W2951320675 cites W2801254079 @default.
• W2951320675 cites W2803072880 @default.
• W2951320675 cites W2805983714 @default.
• W2951320675 cites W2809263049 @default.
• W2951320675 cites W2895675307 @default.
• W2951320675 cites W4234291541 @default.
• W2951320675 doi "https://doi.org/10.1093/ije/dyz124" @default.
• W2951320675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6659372" @default.
• W2951320675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31243447" @default.
• W2951320675 hasPublicationYear "2019" @default.
• W2951320675 type Work @default.
• W2951320675 sameAs 2951320675 @default.
• W2951320675 citedByCount "31" @default.
• W2951320675 countsByYear W29513206752019 @default.
• W2951320675 countsByYear W29513206752020 @default.
• W2951320675 countsByYear W29513206752021 @default.
• W2951320675 countsByYear W29513206752022 @default.
• W2951320675 countsByYear W29513206752023 @default.
• W2951320675 crossrefType "journal-article" @default.
• W2951320675 hasAuthorship W2951320675A5007991040 @default.
• W2951320675 hasAuthorship W2951320675A5013699285 @default.
• W2951320675 hasAuthorship W2951320675A5017728105 @default.
• W2951320675 hasAuthorship W2951320675A5018786162 @default.
• W2951320675 hasAuthorship W2951320675A5019133187 @default.
• W2951320675 hasAuthorship W2951320675A5019844612 @default.
• W2951320675 hasAuthorship W2951320675A5025137857 @default.
• W2951320675 hasAuthorship W2951320675A5026611118 @default.
• W2951320675 hasAuthorship W2951320675A5038891840 @default.
• W2951320675 hasAuthorship W2951320675A5040523850 @default.
• W2951320675 hasAuthorship W2951320675A5040540995 @default.
• W2951320675 hasAuthorship W2951320675A5040933938 @default.
• W2951320675 hasAuthorship W2951320675A5049055281 @default.
• W2951320675 hasAuthorship W2951320675A5050097355 @default.
• W2951320675 hasAuthorship W2951320675A5052267876 @default.
• W2951320675 hasAuthorship W2951320675A5053177403 @default.

• next