FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951331567> ?p ?o ?g. }

• W2951331567 abstract "Tumor associated macrophages (TAMs) are a major type of inflammatory cell in a tumor microenvironment. Previous evidence has suggested that TAMs promote tumorigenesis, growth, invasion and metastasis, thereby affecting tumor metabolism. The mechanisms through which they affect the invasion and metastasis of lung cancer cells remain unclear. The present study investigated the effects and molecular mechanisms of TAMs on the proliferation, invasion and migration of lung adenocarcinoma A549 cells. Human mononuclear leukemia THP‑1 cells were induced into TAMs. The morphological changes that occurred during the induction of the THP‑1 cells were examined with a light microscope. Successful TAM formation was confirmed via flow cytometry. Proliferation, invasion and migration of the lung adenocarcinoma A549 cells were detected by EDU proliferation, scratch wound and Transwell invasion and migration assays, respectively. The expression levels of key proteins involved in the PI3K/AKT signaling pathway were detected by western blot analysis. It was identified that treatment with interleukin (IL)‑4, IL‑13 and Phorbol‑12‑myristate‑13‑acetate successfully induced THP‑1 to form TAMs. The indirect coculture model of TAMs was established by Transwell chamber detection, and the proliferation, invasion and migration ability of lung adenocarcinoma A549 cells were enhanced. Western blot analysis indicated that the expression levels of phosphorylated (p)‑PI3K and p‑AKT proteins were significantly upregulated in the TAMs coculture group compared with that of the blank control group. In summary, the present study demonstrated that TAMs may promote the proliferation, invasion and migration of lung adenocarcinoma A549 cells in vitro, perhaps through the activation of the PI3K/AKT signaling pathway." @default.
• W2951331567 created "2019-06-27" @default.
• W2951331567 creator A5014310116 @default.
• W2951331567 creator A5018257546 @default.
• W2951331567 creator A5053561579 @default.
• W2951331567 creator A5066347620 @default.
• W2951331567 creator A5069135677 @default.
• W2951331567 creator A5071475987 @default.
• W2951331567 creator A5076037377 @default.
• W2951331567 date "2019-06-14" @default.
• W2951331567 modified "2023-10-10" @default.
• W2951331567 title "Tumor‑associated macrophages affect the biological behavior of lung adenocarcinoma A549 cells through the PI3K/AKT signaling pathway" @default.
• W2951331567 cites W1496346239 @default.
• W2951331567 cites W1794190890 @default.
• W2951331567 cites W1987431901 @default.
• W2951331567 cites W1996145004 @default.
• W2951331567 cites W2019240356 @default.
• W2951331567 cites W2026878412 @default.
• W2951331567 cites W2058648826 @default.
• W2951331567 cites W2072114397 @default.
• W2951331567 cites W2075006354 @default.
• W2951331567 cites W2108972938 @default.
• W2951331567 cites W2113082145 @default.
• W2951331567 cites W2123105952 @default.
• W2951331567 cites W2143841612 @default.
• W2951331567 cites W2144556646 @default.
• W2951331567 cites W2162173979 @default.
• W2951331567 cites W2605830629 @default.
• W2951331567 cites W2765398339 @default.
• W2951331567 cites W2770013354 @default.
• W2951331567 cites W2796183066 @default.
• W2951331567 cites W2889646458 @default.
• W2951331567 cites W2890042587 @default.
• W2951331567 cites W2913417421 @default.
• W2951331567 cites W999352312 @default.
• W2951331567 doi "https://doi.org/10.3892/ol.2019.10483" @default.
• W2951331567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6607053" @default.
• W2951331567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31423252" @default.
• W2951331567 hasPublicationYear "2019" @default.
• W2951331567 type Work @default.
• W2951331567 sameAs 2951331567 @default.
• W2951331567 citedByCount "12" @default.
• W2951331567 countsByYear W29513315672020 @default.
• W2951331567 countsByYear W29513315672021 @default.
• W2951331567 countsByYear W29513315672022 @default.
• W2951331567 countsByYear W29513315672023 @default.
• W2951331567 crossrefType "journal-article" @default.
• W2951331567 hasAuthorship W2951331567A5014310116 @default.
• W2951331567 hasAuthorship W2951331567A5018257546 @default.
• W2951331567 hasAuthorship W2951331567A5053561579 @default.
• W2951331567 hasAuthorship W2951331567A5066347620 @default.
• W2951331567 hasAuthorship W2951331567A5069135677 @default.
• W2951331567 hasAuthorship W2951331567A5071475987 @default.
• W2951331567 hasAuthorship W2951331567A5076037377 @default.
• W2951331567 hasBestOaLocation W29513315671 @default.
• W2951331567 hasConcept C121608353 @default.
• W2951331567 hasConcept C137738243 @default.
• W2951331567 hasConcept C142724271 @default.
• W2951331567 hasConcept C1491633281 @default.
• W2951331567 hasConcept C185592680 @default.
• W2951331567 hasConcept C2776107976 @default.
• W2951331567 hasConcept C2776256026 @default.
• W2951331567 hasConcept C2781182431 @default.
• W2951331567 hasConcept C3020616263 @default.
• W2951331567 hasConcept C502942594 @default.
• W2951331567 hasConcept C54355233 @default.
• W2951331567 hasConcept C555283112 @default.
• W2951331567 hasConcept C62112901 @default.
• W2951331567 hasConcept C62478195 @default.
• W2951331567 hasConcept C71924100 @default.
• W2951331567 hasConcept C75217442 @default.
• W2951331567 hasConcept C81729549 @default.
• W2951331567 hasConcept C86554907 @default.
• W2951331567 hasConcept C86803240 @default.
• W2951331567 hasConcept C95444343 @default.
• W2951331567 hasConceptScore W2951331567C121608353 @default.
• W2951331567 hasConceptScore W2951331567C137738243 @default.
• W2951331567 hasConceptScore W2951331567C142724271 @default.
• W2951331567 hasConceptScore W2951331567C1491633281 @default.
• W2951331567 hasConceptScore W2951331567C185592680 @default.
• W2951331567 hasConceptScore W2951331567C2776107976 @default.
• W2951331567 hasConceptScore W2951331567C2776256026 @default.
• W2951331567 hasConceptScore W2951331567C2781182431 @default.
• W2951331567 hasConceptScore W2951331567C3020616263 @default.
• W2951331567 hasConceptScore W2951331567C502942594 @default.
• W2951331567 hasConceptScore W2951331567C54355233 @default.
• W2951331567 hasConceptScore W2951331567C555283112 @default.
• W2951331567 hasConceptScore W2951331567C62112901 @default.
• W2951331567 hasConceptScore W2951331567C62478195 @default.
• W2951331567 hasConceptScore W2951331567C71924100 @default.
• W2951331567 hasConceptScore W2951331567C75217442 @default.
• W2951331567 hasConceptScore W2951331567C81729549 @default.
• W2951331567 hasConceptScore W2951331567C86554907 @default.
• W2951331567 hasConceptScore W2951331567C86803240 @default.
• W2951331567 hasConceptScore W2951331567C95444343 @default.
• W2951331567 hasLocation W29513315671 @default.
• W2951331567 hasLocation W29513315672 @default.
• W2951331567 hasLocation W29513315673 @default.
• W2951331567 hasLocation W29513315674 @default.
• W2951331567 hasOpenAccess W2951331567 @default.

• next