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- W2951336754 abstract "Background Rheumatoid arthritis (RA) is an heterogeneous chronic autoimmune disorder potentially leading to a progressive joint damage with great impact on quality of life. RA pathogenesis is complex and involves environmental factors that trigger disease in genetically susceptible individuals. Extracellular vesicles (EVs) have been described to play an important role in RA pathogenesis and to modulate autoimmune response following environmental exposures, such as air pollution. Objectives Our aim was to evaluate the effects of particulate matter (PM) with aerodynamic diameter ≤ 10 μm (PM10) and ≤ 2.5 μm (PM2.5) on EVs in RA and osteoarthritis (OA) as control. Methods Plasma EVs were analyzed by Nanosight and flow cytometry: CD14 (monocyte/macrophage), CD61 (platelet), CD25 (T-reg), human endogenous retrovirus w (HERV-w), human leukocyte antigen G (HLA-G). Demographic and clinical data were collected for each patient. Plasma EV concentrations were measured in RA and OA patients and were analyzed by generalized linear regression models. Daily PM concentrations, estimated by Regional Environmental Protection Agency at municipality resolution, were used to assign short-term exposure (mean of the 7 days preceding the evaluation) to each patient. Results 12 consecutive patients with RA (median age 68.1, median disease duration 9.3, 12 female, median DAS28 2.25, 5 positive for rheumatoid factors, 6 positive for anti-citrullinated peptide antibodies) and 12 patients with OA (median age 67.1, median disease duration 9.3, 8 female) were enrolled. Analysis of EVs concentration, according to their dimensions, showed a negative association of exosomes (63-92nm) in RA compared to OA (p Conclusion The results of this pilot study show that PM exposure modulates the release of EVs carrying HLA-G and/or HERV-w in RA patients. This might be interpreted as an attempt of immune system to counteract the perturbation provoked by a pro-inflammatory environmental stimulus. More research is still needed to tie the genetic, epigenetic and environmental factors together and to determine their roles in RA pathogenesis. Disclosure of Interests None declared" @default.
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- W2951336754 date "2019-06-01" @default.
- W2951336754 modified "2023-09-23" @default.
- W2951336754 title "AB0141 THE ROLE OF AIR POLLUTION ON EXTRACELLULAR VESICLES AS A POTENTIAL PRO-INFLAMMATORY STIMULUS IN RHEUMATOID ARTHRITIS" @default.
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- W2951336754 doi "https://doi.org/10.1136/annrheumdis-2019-eular.2180" @default.
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