FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951345394> ?p ?o ?g. }

• W2951345394 endingPage "26" @default.
• W2951345394 startingPage "1" @default.
• W2951345394 abstract "Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only gaining in prevalence worldwide. Clinical trials have identified chronic inflammatory disorders as cardiovascular risks, and recent research has revealed a contribution by various inflammatory cells to vascular oxidative stress. Atherosclerosis and cardiovascular disease are closely associated with inflammation, probably due to the close interaction of inflammation with oxidative stress. Classical therapies for inflammatory disorders have demonstrated protective effects in various models of cardiovascular disease; especially established drugs with pleiotropic immunomodulatory properties have proven beneficial cardiovascular effects; normalization of oxidative stress seems to be a common feature of these therapies. The close link between inflammation and redox balance was also supported by reports on aggravated inflammatory phenotype in the absence of antioxidant defense proteins (e.g., superoxide dismutases, heme oxygenase-1, and glutathione peroxidases) or overexpression of reactive oxygen species producing enzymes (e.g., NADPH oxidases). The value of immunomodulation for the treatment of cardiovascular disease was recently supported by large-scale clinical trials demonstrating reduced cardiovascular mortality in patients with established atherosclerotic disease when treated by highly specific anti-inflammatory therapies (e.g., using monoclonal antibodies against cytokines). Modern antidiabetic cardiovascular drugs (e.g., SGLT2 inhibitors, DPP-4 inhibitors, and GLP-1 analogs) seem to share these immunomodulatory properties and display potent antioxidant effects, all of which may explain their successful lowering of cardiovascular risk." @default.
• W2951345394 created "2019-06-27" @default.
• W2951345394 creator A5015861190 @default.
• W2951345394 creator A5032871280 @default.
• W2951345394 creator A5035254382 @default.
• W2951345394 creator A5039361810 @default.
• W2951345394 creator A5039932947 @default.
• W2951345394 creator A5042410979 @default.
• W2951345394 creator A5064993444 @default.
• W2951345394 creator A5066963864 @default.
• W2951345394 creator A5068831026 @default.
• W2951345394 creator A5083135078 @default.
• W2951345394 creator A5090175367 @default.
• W2951345394 date "2019-06-23" @default.
• W2951345394 modified "2023-10-14" @default.
• W2951345394 title "Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease" @default.
• W2951345394 cites W1142449482 @default.
• W2951345394 cites W149477983 @default.
• W2951345394 cites W1509805561 @default.
• W2951345394 cites W1523213544 @default.
• W2951345394 cites W1529592271 @default.
• W2951345394 cites W1558721094 @default.
• W2951345394 cites W1578854399 @default.
• W2951345394 cites W1689732359 @default.
• W2951345394 cites W1699432502 @default.
• W2951345394 cites W170549786 @default.
• W2951345394 cites W1835920973 @default.
• W2951345394 cites W1841286160 @default.
• W2951345394 cites W1850395908 @default.
• W2951345394 cites W1882356554 @default.
• W2951345394 cites W1964911695 @default.
• W2951345394 cites W1965491078 @default.
• W2951345394 cites W1966509801 @default.
• W2951345394 cites W1967172766 @default.
• W2951345394 cites W1968406679 @default.
• W2951345394 cites W1968908220 @default.
• W2951345394 cites W1969422685 @default.
• W2951345394 cites W1971708477 @default.
• W2951345394 cites W1972390741 @default.
• W2951345394 cites W1972632636 @default.
• W2951345394 cites W1972723363 @default.
• W2951345394 cites W1972876739 @default.
• W2951345394 cites W1974661135 @default.
• W2951345394 cites W1974850809 @default.
• W2951345394 cites W1974948897 @default.
• W2951345394 cites W1976702112 @default.
• W2951345394 cites W1977039417 @default.
• W2951345394 cites W1980022623 @default.
• W2951345394 cites W1983102624 @default.
• W2951345394 cites W1983937216 @default.
• W2951345394 cites W1983986440 @default.
• W2951345394 cites W1984061204 @default.
• W2951345394 cites W1984124570 @default.
• W2951345394 cites W1985538633 @default.
• W2951345394 cites W1987066553 @default.
• W2951345394 cites W1989323493 @default.
• W2951345394 cites W1989528047 @default.
• W2951345394 cites W1990031103 @default.
• W2951345394 cites W1991309967 @default.
• W2951345394 cites W1991634110 @default.
• W2951345394 cites W1992014522 @default.
• W2951345394 cites W1993014774 @default.
• W2951345394 cites W1993046839 @default.
• W2951345394 cites W1993952575 @default.
• W2951345394 cites W1994492457 @default.
• W2951345394 cites W2002717271 @default.
• W2951345394 cites W2003434192 @default.
• W2951345394 cites W2008017649 @default.
• W2951345394 cites W2009641136 @default.
• W2951345394 cites W2011124873 @default.
• W2951345394 cites W2011963516 @default.
• W2951345394 cites W2013150924 @default.
• W2951345394 cites W2016632734 @default.
• W2951345394 cites W2017790793 @default.
• W2951345394 cites W2017849767 @default.
• W2951345394 cites W2018607502 @default.
• W2951345394 cites W2021814263 @default.
• W2951345394 cites W2023244494 @default.
• W2951345394 cites W2023415666 @default.
• W2951345394 cites W2023835403 @default.
• W2951345394 cites W2025016774 @default.
• W2951345394 cites W2025227661 @default.
• W2951345394 cites W2025445144 @default.
• W2951345394 cites W2029195231 @default.
• W2951345394 cites W2030300717 @default.
• W2951345394 cites W2030562170 @default.
• W2951345394 cites W2032956793 @default.
• W2951345394 cites W2033060478 @default.
• W2951345394 cites W2035636870 @default.
• W2951345394 cites W2036520729 @default.
• W2951345394 cites W2039014818 @default.
• W2951345394 cites W2044437167 @default.
• W2951345394 cites W2046487710 @default.
• W2951345394 cites W2047392591 @default.
• W2951345394 cites W2049287519 @default.
• W2951345394 cites W2050660416 @default.
• W2951345394 cites W2050663836 @default.
• W2951345394 cites W2051214521 @default.

• next