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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951353973> ?p ?o ?g. }

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• W2951353973 abstract "Ninety-two new 9-norlignan derivatives containing more effective compounds against both cancer and insect cells than lead compounds were synthesized. Against HeLa cells, 7-(3,4-dimethoxyphenyl)-7′-(3′-hydroxy-4′-methoxyphenyl) derivative 63 (IC50 = 0.9 ± 0.2 μM) was to be around 6-fold more potent than lead compound 5. Moreover, against HL-60 cells, 7-(4-trifluoromethylphenyl)-7′-(3′/4′-hydroxyphenyl) derivatives 78 and 79 (IC50 = 2.2 ± 0.4 μM and 2.4 ± 0.6 μM) were 3-fold more potent than lead compound 5. Furthermore, against Sf9 cells from the common cutworm, the 7-(4-trifluoromethylphenyl) derivatives bearing electron-withdrawing groups 76–96 showed a wider range of activity (around 20-fold difference), giving valuable information on the structure–activity relationship. The 7-(4-trifluoromethylphenyl)-7′-(2′/3′-hydroxyphenyl) derivatives 77 and 78 (IC50 = 4.7 ± 0.6 μM and 4.9 ± 0.9 μM) had around 2-fold higher activity against Sf9 cells than lead compound 5. The 7-(4-trifluoromethylphenyl)-7′-(3′-hydroxyphenyl) derivative 78 was also effective against mosquito NIAS-AcAl-2 cells with an IC50 value of 5.4 ± 0.3." @default.
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• W2951353973 date "2019-06-19" @default.
• W2951353973 modified "2023-10-16" @default.
• W2951353973 title "Design of 92 New 9-Norlignan Derivatives and Their Effect on Cell Viabilities of Cancer and Insect Cells" @default.
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• W2951353973 doi "https://doi.org/10.1021/acs.jafc.9b03171" @default.
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