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- W2951381609 abstract "Three new azabicyclic amines, namely exo-3-amino-1-azabicyclo[3.2.1]octane, 3-amino-1-azabicyclo-[3.2.2]nonane and exo-6-amino-8-azabicyclo[3.2.1]octane, have been designed and prepared as isosteres of 3-aminoquinuclidine. Aryl amides derived from each series were prepared and tested in an α7 nicotinic acetylcholine receptor assay as part of a drug discovery program to treat the cognitive deficits in schizophrenia. All new amides showed significant α7 nAChR activity and one series displayed potent α7 activity equal to the quinuclidine series." @default.
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- W2951381609 date "2008-05-13" @default.
- W2951381609 modified "2023-09-28" @default.
- W2951381609 title "ChemInform Abstract: Preparation of Novel Azabicyclic Amines and α7 Nicotinic Acetylcholine Receptor Activity of Derived Aryl Amides." @default.
- W2951381609 cites W2016762393 @default.
- W2951381609 doi "https://doi.org/10.1002/chin.200820163" @default.
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