FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951412477> ?p ?o ?g. }

• W2951412477 abstract "ABSTRACT Brown adipose tissue (BAT) is an important energy metabolic organ that is closely related to obesity, type 2 diabetes, and atherosclerosis. Aging is one of the most important determinants of BAT activity. In this study, we used 18 F-FDG PET/CT imaging to assess the aging of the BAT in Lmna G609G/G609G mice. To evaluate the BAT activity, Lmna G609G/G609G and wild-type (WT) mice were injected with 18F-FDG, and PET/CT imaging was performed. The maximum standardized uptake value (SUV Max ) of the BAT was measured and the target/nontarget (T/NT) values of BAT were calculated. The transcription and the protein expression levels of the uncoupling protein 1 (UCP1), beta3-adrenergic receptor (β3-AR), and the PRdomain-containing16 (PRDM16), were measured by quantitative real-time polymerase chain reaction (RT-PCR) and Western blotting or immunohistochemical analysis. Apoptosis and cell senescence of the BAT, in WT and Lmna G609G/G609G mice, was detected by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and by CDKN2A/p16INK4a immunohistochemical staining, respectively. At 14 weeks of age, the BAT SUV Max and the expression levels of UCP1, β3-AR and PRDM16 in Lmna G609G/G609G mice was significantly lower than that in WT mice. At the same time, the number of p16INK4a and TUNEL positively stained cells (%) increased in Lmna G609G/G609G mice. Lmna G609G/G609G mice are an ideal model for studying BAT aging. The aging characteristics and the aging mechanism of BAT in Lmna G609G/G609G mice can mimic normal BAT aging." @default.
• W2951412477 created "2019-06-27" @default.
• W2951412477 creator A5012375939 @default.
• W2951412477 creator A5018507572 @default.
• W2951412477 creator A5019227415 @default.
• W2951412477 creator A5037677450 @default.
• W2951412477 creator A5049475719 @default.
• W2951412477 creator A5050772776 @default.
• W2951412477 creator A5058550256 @default.
• W2951412477 creator A5065124597 @default.
• W2951412477 creator A5083617985 @default.
• W2951412477 date "2017-11-15" @default.
• W2951412477 modified "2023-09-25" @default.
• W2951412477 title "Assessment of the aging of the brown adipose tissue by 18F-FDG PET/CT imaging in the progeria mouse model LmnaG609G/G609G" @default.
• W2951412477 cites W1537022800 @default.
• W2951412477 cites W1843328901 @default.
• W2951412477 cites W1966524153 @default.
• W2951412477 cites W1975580733 @default.
• W2951412477 cites W1976506286 @default.
• W2951412477 cites W1978274156 @default.
• W2951412477 cites W1995046846 @default.
• W2951412477 cites W2017672706 @default.
• W2951412477 cites W2021128415 @default.
• W2951412477 cites W2032149290 @default.
• W2951412477 cites W2043516115 @default.
• W2951412477 cites W2057683888 @default.
• W2951412477 cites W2062600479 @default.
• W2951412477 cites W2064520939 @default.
• W2951412477 cites W2066442023 @default.
• W2951412477 cites W2093536846 @default.
• W2951412477 cites W2093743108 @default.
• W2951412477 cites W2120207407 @default.
• W2951412477 cites W2122132943 @default.
• W2951412477 cites W2126525177 @default.
• W2951412477 cites W2132358997 @default.
• W2951412477 cites W2134823253 @default.
• W2951412477 cites W2136040666 @default.
• W2951412477 cites W2136490523 @default.
• W2951412477 cites W2141139112 @default.
• W2951412477 cites W2143136139 @default.
• W2951412477 cites W2143185290 @default.
• W2951412477 cites W2151064573 @default.
• W2951412477 cites W2167372092 @default.
• W2951412477 cites W2169781001 @default.
• W2951412477 cites W2205630361 @default.
• W2951412477 cites W2302526767 @default.
• W2951412477 cites W2315073000 @default.
• W2951412477 cites W2573433180 @default.
• W2951412477 cites W2582263353 @default.
• W2951412477 doi "https://doi.org/10.1101/220061" @default.
• W2951412477 hasPublicationYear "2017" @default.
• W2951412477 type Work @default.
• W2951412477 sameAs 2951412477 @default.
• W2951412477 citedByCount "0" @default.
• W2951412477 crossrefType "posted-content" @default.
• W2951412477 hasAuthorship W2951412477A5012375939 @default.
• W2951412477 hasAuthorship W2951412477A5018507572 @default.
• W2951412477 hasAuthorship W2951412477A5019227415 @default.
• W2951412477 hasAuthorship W2951412477A5037677450 @default.
• W2951412477 hasAuthorship W2951412477A5049475719 @default.
• W2951412477 hasAuthorship W2951412477A5050772776 @default.
• W2951412477 hasAuthorship W2951412477A5058550256 @default.
• W2951412477 hasAuthorship W2951412477A5065124597 @default.
• W2951412477 hasAuthorship W2951412477A5083617985 @default.
• W2951412477 hasBestOaLocation W29514124771 @default.
• W2951412477 hasConcept C126322002 @default.
• W2951412477 hasConcept C134018914 @default.
• W2951412477 hasConcept C143128242 @default.
• W2951412477 hasConcept C154113507 @default.
• W2951412477 hasConcept C171089720 @default.
• W2951412477 hasConcept C179093185 @default.
• W2951412477 hasConcept C196795494 @default.
• W2951412477 hasConcept C204232928 @default.
• W2951412477 hasConcept C2780642333 @default.
• W2951412477 hasConcept C2780654407 @default.
• W2951412477 hasConcept C2780723820 @default.
• W2951412477 hasConcept C71924100 @default.
• W2951412477 hasConcept C81979416 @default.
• W2951412477 hasConcept C86803240 @default.
• W2951412477 hasConcept C95444343 @default.
• W2951412477 hasConceptScore W2951412477C126322002 @default.
• W2951412477 hasConceptScore W2951412477C134018914 @default.
• W2951412477 hasConceptScore W2951412477C143128242 @default.
• W2951412477 hasConceptScore W2951412477C154113507 @default.
• W2951412477 hasConceptScore W2951412477C171089720 @default.
• W2951412477 hasConceptScore W2951412477C179093185 @default.
• W2951412477 hasConceptScore W2951412477C196795494 @default.
• W2951412477 hasConceptScore W2951412477C204232928 @default.
• W2951412477 hasConceptScore W2951412477C2780642333 @default.
• W2951412477 hasConceptScore W2951412477C2780654407 @default.
• W2951412477 hasConceptScore W2951412477C2780723820 @default.
• W2951412477 hasConceptScore W2951412477C71924100 @default.
• W2951412477 hasConceptScore W2951412477C81979416 @default.
• W2951412477 hasConceptScore W2951412477C86803240 @default.
• W2951412477 hasConceptScore W2951412477C95444343 @default.
• W2951412477 hasLocation W29514124771 @default.
• W2951412477 hasLocation W29514124772 @default.
• W2951412477 hasOpenAccess W2951412477 @default.
• W2951412477 hasPrimaryLocation W29514124771 @default.
• W2951412477 hasRelatedWork W1592119877 @default.

• next