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• W2951412742 abstract "Efficient synthesis of 3,4-diazabenzo[b]tropone was first achieved utilizing 4π−8π sequential electrocyclic reactions of functionalized benzocyclobutenone derivatives. These compounds are highly electron deficient and readily form amine adducts at ambient temperature. Furthermore, gentle heating resulted in quantitative nitrogen extrusion to produce indenone derivatives. These diazabenzotropones were found to exhibit potent apoptosis-inducing activity against human lymphoma cells. Thus, novel amine-catalyzed nitrogen extrusion reactions and interesting bioactivities were found to be characteristic of these novel diazabenzotropone compounds." @default.
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• W2951412742 date "2009-02-20" @default.
• W2951412742 modified "2023-10-07" @default.
• W2951412742 title "Novel 3,4-Diazabenzotropone Compounds (2,3-Benzodiazepin-5-ones): Synthesis, Unique Reactivity, and Biological Evaluation" @default.
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• W2951412742 doi "https://doi.org/10.1021/ol900154x" @default.
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