FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951420744> ?p ?o ?g. }

• W2951420744 abstract "Neonatal lambs, as other neonates, have physiologically a very low plasma melatonin concentration throughout 24 h. Previously, we found that melatonin given to neonates daily for 5 days decreased heart weight and changed plasma cortisol and gene expression in the adrenal and heart. Whether these changes could compromise the responses to life challenges is unknown. Therefore, firstly, we studied acute effects of melatonin on the defense mechanisms to acute hypoxia in the neonate. Eleven lambs, 2 weeks old, were instrumented and subjected to an episode of acute isocapnic hypoxia, consisting of four 30 min periods: normoxia (room air), normoxia after an i.v. bolus of melatonin (0.27 mg kg-1, n = 6) or vehicle (ethanol 1:10 NaCl 0.9%, n = 5), hypoxia (PaO2: 30 ± 2 mmHg), and recovery (room air). Mean pulmonary and systemic blood pressures, heart rate, and cardiac output were measured, and systemic and pulmonary vascular resistance and stroke volume were calculated. Blood samples were taken every 30 min to measure plasma norepinephrine, cortisol, glucose, triglycerides, and redox markers (8-isoprostane and FRAP). Melatonin blunted the increase of pulmonary vascular resistance triggered by hypoxia, markedly exacerbated the heart rate response, decreased heart stroke volume, and lessened the magnitude of the increase of plasmatic norepinephrine and cortisol levels induced by hypoxia. No changes were observed in pulmonary blood pressure, systemic blood pressures and resistance, cardiac output, glucose, triglyceride plasma concentrations, or redox markers. Melatonin had no effect on cardiovascular, endocrine, or metabolic variables, under normoxia. Secondly, we examined whether acute melatonin administration under normoxia could have an effect in gene expression on the adrenal, lung, and heart. Lambs received a bolus of vehicle or melatonin and were euthanized 30 min later to collect tissues. We found that melatonin affected expression of the immediate early genes egr1 in adrenal, ctgf in lung, and nr3c1, the glucocorticoid receptor, in adrenal and heart. We speculate that these early gene responses may contribute to the observed alterations of the newborn defense mechanisms to hypoxia. This could be particularly important since the use of melatonin is proposed for several diseases in the neonatal period in humans." @default.
• W2951420744 created "2019-06-27" @default.
• W2951420744 creator A5010566384 @default.
• W2951420744 creator A5010763514 @default.
• W2951420744 creator A5032007168 @default.
• W2951420744 creator A5064116442 @default.
• W2951420744 creator A5069311372 @default.
• W2951420744 creator A5075737721 @default.
• W2951420744 creator A5078498546 @default.
• W2951420744 creator A5080583819 @default.
• W2951420744 creator A5085000979 @default.
• W2951420744 creator A5090156858 @default.
• W2951420744 date "2019-07-12" @default.
• W2951420744 modified "2023-09-23" @default.
• W2951420744 title "Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs" @default.
• W2951420744 cites W1485887944 @default.
• W2951420744 cites W1511863177 @default.
• W2951420744 cites W1875915783 @default.
• W2951420744 cites W1938685379 @default.
• W2951420744 cites W1943296211 @default.
• W2951420744 cites W1963032031 @default.
• W2951420744 cites W1963588569 @default.
• W2951420744 cites W1964219654 @default.
• W2951420744 cites W1965116772 @default.
• W2951420744 cites W1968125281 @default.
• W2951420744 cites W1969450848 @default.
• W2951420744 cites W1971627429 @default.
• W2951420744 cites W1972753027 @default.
• W2951420744 cites W1979054346 @default.
• W2951420744 cites W1980541694 @default.
• W2951420744 cites W1980732917 @default.
• W2951420744 cites W1980802767 @default.
• W2951420744 cites W1985073831 @default.
• W2951420744 cites W1985569332 @default.
• W2951420744 cites W1993651993 @default.
• W2951420744 cites W1997744799 @default.
• W2951420744 cites W2004886793 @default.
• W2951420744 cites W2009999546 @default.
• W2951420744 cites W2013233045 @default.
• W2951420744 cites W2015546336 @default.
• W2951420744 cites W2019394392 @default.
• W2951420744 cites W2020568052 @default.
• W2951420744 cites W2023811811 @default.
• W2951420744 cites W2033321521 @default.
• W2951420744 cites W2043373424 @default.
• W2951420744 cites W2049004260 @default.
• W2951420744 cites W2051152628 @default.
• W2951420744 cites W2059881173 @default.
• W2951420744 cites W2073151950 @default.
• W2951420744 cites W207896504 @default.
• W2951420744 cites W2082407123 @default.
• W2951420744 cites W2082484704 @default.
• W2951420744 cites W2085727131 @default.
• W2951420744 cites W2092647381 @default.
• W2951420744 cites W2106303814 @default.
• W2951420744 cites W2112861506 @default.
• W2951420744 cites W2116214322 @default.
• W2951420744 cites W2117186834 @default.
• W2951420744 cites W2120230757 @default.
• W2951420744 cites W2122448497 @default.
• W2951420744 cites W2123179186 @default.
• W2951420744 cites W2127354161 @default.
• W2951420744 cites W2132681815 @default.
• W2951420744 cites W2139830807 @default.
• W2951420744 cites W2141855318 @default.
• W2951420744 cites W2142029222 @default.
• W2951420744 cites W2149763277 @default.
• W2951420744 cites W2157611470 @default.
• W2951420744 cites W2159950146 @default.
• W2951420744 cites W2168035958 @default.
• W2951420744 cites W2326552723 @default.
• W2951420744 cites W2326807095 @default.
• W2951420744 cites W2349918789 @default.
• W2951420744 cites W2409853080 @default.
• W2951420744 cites W2468471556 @default.
• W2951420744 cites W2491820136 @default.
• W2951420744 cites W2568635050 @default.
• W2951420744 cites W2732295576 @default.
• W2951420744 cites W2736119483 @default.
• W2951420744 cites W2737780923 @default.
• W2951420744 cites W2788678475 @default.
• W2951420744 cites W2889179890 @default.
• W2951420744 cites W2911723925 @default.
• W2951420744 cites W4233013459 @default.
• W2951420744 doi "https://doi.org/10.3389/fendo.2019.00433" @default.
• W2951420744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6640618" @default.
• W2951420744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31354619" @default.
• W2951420744 hasPublicationYear "2019" @default.
• W2951420744 type Work @default.
• W2951420744 sameAs 2951420744 @default.
• W2951420744 citedByCount "5" @default.
• W2951420744 countsByYear W29514207442021 @default.
• W2951420744 countsByYear W29514207442022 @default.
• W2951420744 countsByYear W29514207442023 @default.
• W2951420744 crossrefType "journal-article" @default.
• W2951420744 hasAuthorship W2951420744A5010566384 @default.
• W2951420744 hasAuthorship W2951420744A5010763514 @default.
• W2951420744 hasAuthorship W2951420744A5032007168 @default.
• W2951420744 hasAuthorship W2951420744A5064116442 @default.
• W2951420744 hasAuthorship W2951420744A5069311372 @default.

• next