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- W2951428735 abstract "Background and aims A cerebrospinal fluid (CSF) red to white cell correction ratio of 500:1 is often quoted as a preliminary result for determining potential positive/negative CSF cultures. The aim of this study is to examine the diagnostic utility of correcting white blood cells (WBC) counts in CSF based on 500:1 ratio and to evaluate this adjustment in identifying bacterial meningitis prior to final culture in infants. Method We performed a cohort study on children younger than 3 months who admitted to Our Lady’s Children’s Hospital, Crumlin, with suspected sepsis from the 1st October 2017 to the 05th October 2018. CSF WBC counts were adjusted downward for traumatic lumbar punctures (RBCs > 500/mm3) using white to red cells (500:1) ratio. We calculated sensitivity, specificity, positive productive value (PPV) and negative productive value (NPV) of unadjusted and adjusted WBC count in traumatic CSF for predicting bacterial meningitis. Result A total of 117 infants (age: 39.4±21.7 days, male: 85(72.6%), traumatic lumber puncture: 35(29.9%)) were enrolled in this study. Among 117 infants, 3 (2.6%) had positive CSF cultures for bacterial meningitis, 28 (23.9%) had viral meningitis. Compared with the unadjusted cerebrospinal fluid WBC count, the adjusted one had similar sensitivity, PPV and NPV for bacterial meningitis. NPV and PPV of adjusted CSF WBC count were 100% and 14.2%, respectively (sensitivity 100%, specificity 82%). While NPV and PPV of unadjusted one were 100% and 5.8%, respectively (sensitivity 100%, specificity 52%). Conclusion Adjusted WBC counts in CSF have no advantage over uncorrected counts for predicting bacterial meningitis. All available clinical and laboratory data should be used when deciding whether to institute treatment in an infant with suspected meningitis and bloody CSF." @default.
- W2951428735 created "2019-06-27" @default.
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- W2951428735 date "2019-06-01" @default.
- W2951428735 modified "2023-09-26" @default.
- W2951428735 title "GP199 Cell ratios in traumatic cerebrospinal fluid. do they have predictive value for meningitis?" @default.
- W2951428735 doi "https://doi.org/10.1136/archdischild-2019-epa.259" @default.
- W2951428735 hasPublicationYear "2019" @default.
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