FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951429537> ?p ?o ?g. }

• W2951429537 endingPage "404" @default.
• W2951429537 startingPage "400" @default.
• W2951429537 abstract "Eight flavonoids, namely naringenin 1, 3-β-hydroxynaringenin designated as isoaromadendrin 2, taxifolin 3, isoaromadendrin-7-O-β-D-glucopyranoside designated as isosinensin 4 have been isolated from Euphorbia cuneata Vahl; 5hydroxy-3, 4′, 7-trimethoxyflavone 5, 5-hydroxy-3, 3′, 4′, 7-tetramethoxyflavone (retusin) 6, 4′, 5-dihydroxyflavone-5-O-βD-glucopyranoside named as verbenacoside 7 are obtained from Salvia verbenaca L; and epicatchin 8 is isolated from Osyris abyssinica. Their structures have been established by spectral and chemical methods, whereupon the compounds 2, 4 and 7 are found to be new flavonoids. Compounds 1-5, 7, 8 and alcoholic extract of Salvia verbenaca have also been screened biologically for antihypertensive activity in normotensive albino rats, which showed a varied degree in the decrease of blood pressure and heart rate. The flavonoids 2, 3 and 5 are found most potent exhibiting the decrease in blood pressure 36.5, 20.0 and 30.0 (mmHg) respectively in comparison to normal values. Other compounds also exhibit a good activity. The structure activity relationship (SAR) has also been discussed. IPC: Int.Cl. 7 C 07 D 311/30 The flavonoids are considered potential for human health as well as constitute an important part of human diet. They are also considered as active principles in various medicinal plants 1 , and have been reported to possess anticancer, antioxidant, antimicrobial, antihypertensive, antiulcer, antipyretic and antidiabetic properties etc. In the present article we report the isolation of some flavonoids, three of them new, from Euphorbia cuneata, Salvia verbenaca and Osyris abyssinica, and evaluation of their antihypertensive activity by measuring the arterial blood pressure and heart rate in normotensive albino rats. Euphorbia cuneata (Euphorbiaceae), locally known as Abu-Laban is reported to be used for the treatment of ringworm, scorpion sting and snake bite by the traditional medicine practitioners of Saudi Arabia 2 . We have isolated naringenin 1, 3-βhydroxynaringenin designated as isoaromadendrin 2, taxifolin 3 and isoaromadendrin-7-O-β-D-glucopyranoside designated as isosinensin 4 from the alcoholic extract of aerial parts of the plant. Salvia verbenaca L. (Labiatae) is distributed in tropical region including Saudi Arabia. The alcoholic extract of the aerial parts has been reported to potentiate smooth muscle contractions induced by acetylcholine, histamine, BaCl2, and serotonin 3 . We have isolated 5-hydroxy-3, 4′, 7-trimethoxyflavone 5, 5-hydroxy-3,3′,4′,7-tetramethoxyflavone (retusin) 6 and 4′,5-dihydroxy flavone-5-O-β-D-glucopyranoside designated as verbenacoside 7 from the alcoholic extract of aerial parts of the plant. The plant Osyris abyssinica var. speciosa (Santalaceae) is distributed in South Africa including Saudi Arabia 4 . We have isolated epicatechin 8 from the aerial parts of the plant. The literature survey revealed that the antihypertensive activity of the above flavonoids has not yet been reported so far. We have, therefore, tested the above flavonoids and ethanolic extract of Salvia verbenaca for their antihypertensive activity, which showed a significant decrease in blood pressure and heart rate in normotensive albino rats, wherein the compounds 2, 3 and 5 were found most potent exhibiting 36.5, 20.0 and 30.0 (mmHg) decrease in blood pressure respectively. Other compounds also displayed a good decrease in blood pressure and heart rate." @default.
• W2951429537 created "2019-06-27" @default.
• W2951429537 creator A5008188539 @default.
• W2951429537 creator A5037591141 @default.
• W2951429537 creator A5042875619 @default.
• W2951429537 creator A5091365236 @default.
• W2951429537 date "2005-02-01" @default.
• W2951429537 modified "2023-09-26" @default.
• W2951429537 title "Isolation, antihypertensive activity and structure activity relationship of flavonoids from three medicinal plants" @default.
• W2951429537 cites W198701619 @default.
• W2951429537 cites W2094498700 @default.
• W2951429537 cites W2405274570 @default.
• W2951429537 cites W960706032 @default.
• W2951429537 hasPublicationYear "2005" @default.
• W2951429537 type Work @default.
• W2951429537 sameAs 2951429537 @default.
• W2951429537 citedByCount "1" @default.
• W2951429537 crossrefType "journal-article" @default.
• W2951429537 hasAuthorship W2951429537A5008188539 @default.
• W2951429537 hasAuthorship W2951429537A5037591141 @default.
• W2951429537 hasAuthorship W2951429537A5042875619 @default.
• W2951429537 hasAuthorship W2951429537A5091365236 @default.
• W2951429537 hasConcept C178790620 @default.
• W2951429537 hasConcept C185592680 @default.
• W2951429537 hasConcept C2776473397 @default.
• W2951429537 hasConcept C2776848411 @default.
• W2951429537 hasConcept C2778004101 @default.
• W2951429537 hasConcept C2778719679 @default.
• W2951429537 hasConcept C2779054382 @default.
• W2951429537 hasConcept C2779158651 @default.
• W2951429537 hasConcept C2779880300 @default.
• W2951429537 hasConcept C4937899 @default.
• W2951429537 hasConcept C55493867 @default.
• W2951429537 hasConcept C556039675 @default.
• W2951429537 hasConcept C71924100 @default.
• W2951429537 hasConceptScore W2951429537C178790620 @default.
• W2951429537 hasConceptScore W2951429537C185592680 @default.
• W2951429537 hasConceptScore W2951429537C2776473397 @default.
• W2951429537 hasConceptScore W2951429537C2776848411 @default.
• W2951429537 hasConceptScore W2951429537C2778004101 @default.
• W2951429537 hasConceptScore W2951429537C2778719679 @default.
• W2951429537 hasConceptScore W2951429537C2779054382 @default.
• W2951429537 hasConceptScore W2951429537C2779158651 @default.
• W2951429537 hasConceptScore W2951429537C2779880300 @default.
• W2951429537 hasConceptScore W2951429537C4937899 @default.
• W2951429537 hasConceptScore W2951429537C55493867 @default.
• W2951429537 hasConceptScore W2951429537C556039675 @default.
• W2951429537 hasConceptScore W2951429537C71924100 @default.
• W2951429537 hasIssue "2" @default.
• W2951429537 hasLocation W29514295371 @default.
• W2951429537 hasOpenAccess W2951429537 @default.
• W2951429537 hasPrimaryLocation W29514295371 @default.
• W2951429537 hasRelatedWork W1183440274 @default.
• W2951429537 hasRelatedWork W1881029786 @default.
• W2951429537 hasRelatedWork W1974982507 @default.
• W2951429537 hasRelatedWork W2021905887 @default.
• W2951429537 hasRelatedWork W2027854979 @default.
• W2951429537 hasRelatedWork W2070397360 @default.
• W2951429537 hasRelatedWork W2071299460 @default.
• W2951429537 hasRelatedWork W2078394773 @default.
• W2951429537 hasRelatedWork W2087233524 @default.
• W2951429537 hasRelatedWork W2116201685 @default.
• W2951429537 hasRelatedWork W2130993490 @default.
• W2951429537 hasRelatedWork W2154708046 @default.
• W2951429537 hasRelatedWork W2326210357 @default.
• W2951429537 hasRelatedWork W2396517099 @default.
• W2951429537 hasRelatedWork W2401993508 @default.
• W2951429537 hasRelatedWork W2406255816 @default.
• W2951429537 hasRelatedWork W2777541832 @default.
• W2951429537 hasRelatedWork W2927129404 @default.
• W2951429537 hasRelatedWork W2951970010 @default.
• W2951429537 hasRelatedWork W3127217171 @default.
• W2951429537 hasVolume "44" @default.
• W2951429537 isParatext "false" @default.
• W2951429537 isRetracted "false" @default.
• W2951429537 magId "2951429537" @default.
• W2951429537 workType "article" @default.