Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951441937> ?p ?o ?g. }
- W2951441937 endingPage "3548" @default.
- W2951441937 startingPage "3537" @default.
- W2951441937 abstract "Complex cutaneous wounds like diabetic foot ulcers represent a critical clinical challenge and demand a large-scale and low-cost strategy for effective treatment. Herein, we use a rabbit animal model to investigate efficacy of bioactive wound dressings made up of silk biomaterials. Nanofibrous mats of Antheraea assama silkworm silk fibroin (AaSF) are coated with various recombinant spider silk fusion proteins through silk–silk interactions to fabricate multifunctional wound dressings. Two different types of spider silk coatings are used to compare their healing efficiency: FN-4RepCT (contains a cell binding motif derived from fibronectin) and Lac-4RepCT (contains a cationic antimicrobial peptide from lactoferricin). AaSF mats coated with spider silk show accelerated wound healing properties in comparison to the uncoated mats. Among the spider silk coated variants, dual coating of FN-4RepCT and Lac-4RepCT on top of AaSF mat demonstrated better wound healing efficiency, followed by FN-4RepCT and Lac-4RepCT single coated counterparts. The in vivo study also reveals excellent skin regeneration by the functionalized silk dressings in comparison to commercially used Duoderm dressing and untreated wounds. The spider silk coatings demonstrate early granulation tissue development, re-epithelialization, and efficient matrix remodelling of wounds. The results thus validate potential of bioactive silk matrices in faster repair of diabetic wounds." @default.
- W2951441937 created "2019-06-27" @default.
- W2951441937 creator A5000334897 @default.
- W2951441937 creator A5029253171 @default.
- W2951441937 creator A5069251404 @default.
- W2951441937 creator A5072175984 @default.
- W2951441937 creator A5086164115 @default.
- W2951441937 date "2019-06-06" @default.
- W2951441937 modified "2023-10-18" @default.
- W2951441937 title "Silkworm Silk Matrices Coated with Functionalized Spider Silk Accelerate Healing of Diabetic Wounds" @default.
- W2951441937 cites W1576283994 @default.
- W2951441937 cites W1880461483 @default.
- W2951441937 cites W1965324241 @default.
- W2951441937 cites W1976393051 @default.
- W2951441937 cites W1991552237 @default.
- W2951441937 cites W1997947168 @default.
- W2951441937 cites W2019711191 @default.
- W2951441937 cites W2022301246 @default.
- W2951441937 cites W2023860667 @default.
- W2951441937 cites W2026999028 @default.
- W2951441937 cites W2038752716 @default.
- W2951441937 cites W2051554704 @default.
- W2951441937 cites W2053992512 @default.
- W2951441937 cites W2056064788 @default.
- W2951441937 cites W2065843100 @default.
- W2951441937 cites W2077090481 @default.
- W2951441937 cites W2078668750 @default.
- W2951441937 cites W2080207900 @default.
- W2951441937 cites W2112145198 @default.
- W2951441937 cites W2114286636 @default.
- W2951441937 cites W2117808317 @default.
- W2951441937 cites W2120472250 @default.
- W2951441937 cites W2133602801 @default.
- W2951441937 cites W2143486607 @default.
- W2951441937 cites W2152773911 @default.
- W2951441937 cites W2157908104 @default.
- W2951441937 cites W2165449668 @default.
- W2951441937 cites W2217592530 @default.
- W2951441937 cites W2220130694 @default.
- W2951441937 cites W2254714261 @default.
- W2951441937 cites W2331260730 @default.
- W2951441937 cites W2508817873 @default.
- W2951441937 cites W2530589003 @default.
- W2951441937 cites W2551545217 @default.
- W2951441937 cites W2588991598 @default.
- W2951441937 cites W2619101941 @default.
- W2951441937 cites W2746712943 @default.
- W2951441937 cites W2761724645 @default.
- W2951441937 cites W2761940021 @default.
- W2951441937 cites W2774372483 @default.
- W2951441937 cites W2811454477 @default.
- W2951441937 cites W2885057521 @default.
- W2951441937 cites W2899349321 @default.
- W2951441937 cites W2900709212 @default.
- W2951441937 doi "https://doi.org/10.1021/acsbiomaterials.9b00514" @default.
- W2951441937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33405736" @default.
- W2951441937 hasPublicationYear "2019" @default.
- W2951441937 type Work @default.
- W2951441937 sameAs 2951441937 @default.
- W2951441937 citedByCount "20" @default.
- W2951441937 countsByYear W29514419372019 @default.
- W2951441937 countsByYear W29514419372020 @default.
- W2951441937 countsByYear W29514419372021 @default.
- W2951441937 countsByYear W29514419372022 @default.
- W2951441937 countsByYear W29514419372023 @default.
- W2951441937 crossrefType "journal-article" @default.
- W2951441937 hasAuthorship W2951441937A5000334897 @default.
- W2951441937 hasAuthorship W2951441937A5029253171 @default.
- W2951441937 hasAuthorship W2951441937A5069251404 @default.
- W2951441937 hasAuthorship W2951441937A5072175984 @default.
- W2951441937 hasAuthorship W2951441937A5086164115 @default.
- W2951441937 hasConcept C104317684 @default.
- W2951441937 hasConcept C122302759 @default.
- W2951441937 hasConcept C136229726 @default.
- W2951441937 hasConcept C141071460 @default.
- W2951441937 hasConcept C159985019 @default.
- W2951441937 hasConcept C185592680 @default.
- W2951441937 hasConcept C189165786 @default.
- W2951441937 hasConcept C192562407 @default.
- W2951441937 hasConcept C206767735 @default.
- W2951441937 hasConcept C2776847223 @default.
- W2951441937 hasConcept C2778487026 @default.
- W2951441937 hasConcept C2780181586 @default.
- W2951441937 hasConcept C2780269544 @default.
- W2951441937 hasConcept C2780431358 @default.
- W2951441937 hasConcept C55493867 @default.
- W2951441937 hasConcept C71924100 @default.
- W2951441937 hasConcept C86492073 @default.
- W2951441937 hasConcept C86803240 @default.
- W2951441937 hasConcept C90856448 @default.
- W2951441937 hasConceptScore W2951441937C104317684 @default.
- W2951441937 hasConceptScore W2951441937C122302759 @default.
- W2951441937 hasConceptScore W2951441937C136229726 @default.
- W2951441937 hasConceptScore W2951441937C141071460 @default.
- W2951441937 hasConceptScore W2951441937C159985019 @default.
- W2951441937 hasConceptScore W2951441937C185592680 @default.
- W2951441937 hasConceptScore W2951441937C189165786 @default.
- W2951441937 hasConceptScore W2951441937C192562407 @default.