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- W2951445839 abstract "Growth differentiation factors 1 (GDF1) and 3 (GDF3) are members of the transforming growth factor superfamily (TGF-β) that is involved in fundamental early-developmental processes that are conserved across vertebrates. The evolutionary history of these genes is still under debate due to ambiguous definitions of homologous relationships among vertebrates. Thus, the goal of this study was to unravel the evolution of the GDF1 and GDF3 genes of vertebrates, emphasizing the understanding of homologous relationships and their evolutionary origin. Our results revealed that the GDF1 and GDF3 genes found in anurans and mammals are the products of independent duplication events of an ancestral gene in the ancestor of each of these lineages. The main implication of this result is that the GDF1 and GDF3 genes of anurans and mammals are not 1:1 orthologs. In other words, genes that participate in fundamental processes during early development have been reinvented two independent times during the evolutionary history of tetrapods." @default.
- W2951445839 created "2019-06-27" @default.
- W2951445839 creator A5010879323 @default.
- W2951445839 creator A5053052855 @default.
- W2951445839 date "2018-09-11" @default.
- W2951445839 modified "2023-10-12" @default.
- W2951445839 title "Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals" @default.
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- W2951445839 doi "https://doi.org/10.1038/s41598-018-31954-w" @default.
- W2951445839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134012" @default.
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