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- W2951445876 abstract "Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR), a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay for the physical detection of D-loops in vivo, which enabled studying the kinetics of their formation and defining the activities controlling their metabolism. Nascent D-loops are detected within 2 h of DSB formation and extended in a delayed fashion in a genetic system designed to preclude downstream repair steps. The majority of nascent D-loops are disrupted by two pathways: one supported by the Srs2 helicase and the other by the Mph1 helicase and the Sgs1-Top3-Rmi1 helicase-topoisomerase complex. Both pathways operate without significant overlap and are delineated by the Rad54 paralog Rdh54 in an ATPase-independent fashion. This study uncovers a layer of quality control of HR relying on nascent D-loop dynamics." @default.
- W2951445876 created "2019-06-27" @default.
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- W2951445876 date "2019-03-01" @default.
- W2951445876 modified "2023-10-18" @default.
- W2951445876 title "Dynamic Processing of Displacement Loops during Recombinational DNA Repair" @default.
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- W2951445876 doi "https://doi.org/10.1016/j.molcel.2019.01.005" @default.
- W2951445876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6532985" @default.
- W2951445876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30737186" @default.
- W2951445876 hasPublicationYear "2019" @default.
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