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- W2951472018 abstract "The gastric lamina propria of mice that have been experimentally infected with the pathobiont Helicobacter pylori hosts a dense network of myeloid cells that includes BATF3-dependent CD103+ dendritic cells (DCs). We show here that CD103+ DCs are strictly required for gastric Th1 responses to H. pylori and for H. pylori infection control. A similar dependence of type 1 immunity on CD103+ DCs is observed in a Mycobacterium bovis BCG infection model, and in a syngeneic colon cancer model. Strikingly, we find that not only the expansion and/or recruitment of Th1 cells, but also of peripherally induced, neuropilin-negative regulatory T-cells to sites of infection requires BATF3-dependent DCs. A shared feature of the examined models is the strongly reduced production of the chemokines and CXCR3 ligands CXCL9, 10 and 11 in BATF3-deficient mice. The results implicate BATF3-dependent DCs in the recruitment of CXCR3+ effector and regulatory T-cells to target tissues and in their local expansion." @default.
- W2951472018 created "2019-06-27" @default.
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- W2951472018 date "2019-06-12" @default.
- W2951472018 modified "2023-10-16" @default.
- W2951472018 title "BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues" @default.
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- W2951472018 doi "https://doi.org/10.1371/journal.ppat.1007866" @default.
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