FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951475560> ?p ?o ?g. }

• W2951475560 endingPage "713" @default.
• W2951475560 startingPage "705" @default.
• W2951475560 abstract "Silk fibroin has been utilized extensively for biomedical purposes, especially the drug delivery systems. This study introduced and characterized three novel α-mangostin loaded crosslinked fibroin nanoparticles (FNPs), using EDC or PEI as a crosslinker, for cancer treatment. All three formulas were spherical particles with a mean size of approximately 300 nm. By varying the type and/or amount of the crosslinkers, particle surface charge was controllable from −15 to +30 mV. Crosslinked FNPs exhibited higher drug entrapment efficiency (70%) and drug loading (7%) than non-crosslinked FNP. FT-IR, XRD, and DSC analytical methods confirmed that α-mangostin was entrapped in FNPs in molecular dispersion form. Compared to the free α-mangostin, the crosslinked FNPs increased the drug’s solubility up to threefold. They also showed sustained release characteristics of more than 3 days, and reduced free α-mangostin hematotoxicity by 90%. The α-mangostin loaded FNPs were physicochemically stable for up to 24 h when dispersed in intravenous diluent and for at least 6 months when preserved as lyophilized powder at 4 °C. In terms of anticancer efficacy, on both Caco-2 colorectal and MCF-7 breast adenocarcinoma cell lines, all formulas maintain α-mangostin’s apoptotic effect while exhibit greater cytotoxicity than the free drug. In conclusion, α-mangostin loaded crosslinked FNPs show high potential for cancer chemotherapy." @default.
• W2951475560 created "2019-06-27" @default.
• W2951475560 creator A5038068417 @default.
• W2951475560 creator A5043173294 @default.
• W2951475560 creator A5086738391 @default.
• W2951475560 date "2019-09-01" @default.
• W2951475560 modified "2023-10-15" @default.
• W2951475560 title "Alpha mangostin loaded crosslinked silk fibroin-based nanoparticles for cancer chemotherapy" @default.
• W2951475560 cites W1970685148 @default.
• W2951475560 cites W1977256998 @default.
• W2951475560 cites W1980419847 @default.
• W2951475560 cites W1991058890 @default.
• W2951475560 cites W2006300353 @default.
• W2951475560 cites W2007888561 @default.
• W2951475560 cites W2020281991 @default.
• W2951475560 cites W2031708844 @default.
• W2951475560 cites W2034459082 @default.
• W2951475560 cites W2044733684 @default.
• W2951475560 cites W2072002929 @default.
• W2951475560 cites W2082387225 @default.
• W2951475560 cites W2087812848 @default.
• W2951475560 cites W2093841140 @default.
• W2951475560 cites W2094399039 @default.
• W2951475560 cites W2106241844 @default.
• W2951475560 cites W2109453910 @default.
• W2951475560 cites W2125055777 @default.
• W2951475560 cites W2140299645 @default.
• W2951475560 cites W2145868082 @default.
• W2951475560 cites W2147000598 @default.
• W2951475560 cites W2155174755 @default.
• W2951475560 cites W2159559294 @default.
• W2951475560 cites W2165453779 @default.
• W2951475560 cites W2178561795 @default.
• W2951475560 cites W2337563667 @default.
• W2951475560 cites W2519470903 @default.
• W2951475560 cites W2748218427 @default.
• W2951475560 cites W2766452553 @default.
• W2951475560 cites W2773651656 @default.
• W2951475560 cites W2804425744 @default.
• W2951475560 cites W2878450749 @default.
• W2951475560 cites W2889597197 @default.
• W2951475560 doi "https://doi.org/10.1016/j.colsurfb.2019.06.011" @default.
• W2951475560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31228853" @default.
• W2951475560 hasPublicationYear "2019" @default.
• W2951475560 type Work @default.
• W2951475560 sameAs 2951475560 @default.
• W2951475560 citedByCount "49" @default.
• W2951475560 countsByYear W29514755602019 @default.
• W2951475560 countsByYear W29514755602020 @default.
• W2951475560 countsByYear W29514755602021 @default.
• W2951475560 countsByYear W29514755602022 @default.
• W2951475560 countsByYear W29514755602023 @default.
• W2951475560 crossrefType "journal-article" @default.
• W2951475560 hasAuthorship W2951475560A5038068417 @default.
• W2951475560 hasAuthorship W2951475560A5043173294 @default.
• W2951475560 hasAuthorship W2951475560A5086738391 @default.
• W2951475560 hasConcept C109316439 @default.
• W2951475560 hasConcept C110884469 @default.
• W2951475560 hasConcept C122302759 @default.
• W2951475560 hasConcept C127413603 @default.
• W2951475560 hasConcept C13965031 @default.
• W2951475560 hasConcept C147789679 @default.
• W2951475560 hasConcept C155574463 @default.
• W2951475560 hasConcept C155672457 @default.
• W2951475560 hasConcept C159985019 @default.
• W2951475560 hasConcept C171250308 @default.
• W2951475560 hasConcept C178790620 @default.
• W2951475560 hasConcept C185592680 @default.
• W2951475560 hasConcept C187530423 @default.
• W2951475560 hasConcept C192562407 @default.
• W2951475560 hasConcept C202751555 @default.
• W2951475560 hasConcept C2780431358 @default.
• W2951475560 hasConcept C42360764 @default.
• W2951475560 hasConcept C521977710 @default.
• W2951475560 hasConcept C55493867 @default.
• W2951475560 hasConceptScore W2951475560C109316439 @default.
• W2951475560 hasConceptScore W2951475560C110884469 @default.
• W2951475560 hasConceptScore W2951475560C122302759 @default.
• W2951475560 hasConceptScore W2951475560C127413603 @default.
• W2951475560 hasConceptScore W2951475560C13965031 @default.
• W2951475560 hasConceptScore W2951475560C147789679 @default.
• W2951475560 hasConceptScore W2951475560C155574463 @default.
• W2951475560 hasConceptScore W2951475560C155672457 @default.
• W2951475560 hasConceptScore W2951475560C159985019 @default.
• W2951475560 hasConceptScore W2951475560C171250308 @default.
• W2951475560 hasConceptScore W2951475560C178790620 @default.
• W2951475560 hasConceptScore W2951475560C185592680 @default.
• W2951475560 hasConceptScore W2951475560C187530423 @default.
• W2951475560 hasConceptScore W2951475560C192562407 @default.
• W2951475560 hasConceptScore W2951475560C202751555 @default.
• W2951475560 hasConceptScore W2951475560C2780431358 @default.
• W2951475560 hasConceptScore W2951475560C42360764 @default.
• W2951475560 hasConceptScore W2951475560C521977710 @default.
• W2951475560 hasConceptScore W2951475560C55493867 @default.
• W2951475560 hasFunder F4320322614 @default.
• W2951475560 hasFunder F4320323020 @default.
• W2951475560 hasLocation W29514755601 @default.
• W2951475560 hasLocation W29514755602 @default.

• next