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- W2951484106 abstract "A library of 35 cis-1-benzoyl-2-methyl-4-(phenylamino)-1,2,3,4-tetrahydroquinolines was prepared. The compounds bore various substitutuents on the benzoyl ring, at the 4-position of the phenylamino ring and at the 6-position of the tetrahydroquinoline ring. The compounds were assayed for their ability to cause expression of a reporter gene downstream of an ecdysone response element in a mammalian cell line engineered to express the ecdysone receptor from Aedes aegypti. In general, compounds with small lipophilic substituents at the meta and para-positions of the benzoyl ring and hydrogen or fluorine at the 4-position of the phenylamino ring and the 6-position of the tetrahydroquinoline ring were the most potent." @default.
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- W2951484106 date "2003-09-02" @default.
- W2951484106 modified "2023-09-26" @default.
- W2951484106 title "Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline Ligands for Control of Gene Expression in Ecdysone Responsive Systems." @default.
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- W2951484106 doi "https://doi.org/10.1002/chin.200335116" @default.
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