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• W2951488903 endingPage "e0195625" @default.
• W2951488903 startingPage "e0195625" @default.
• W2951488903 abstract "The Florida manatee (Trichechus manatus latirotris) is a threatened aquatic mammal in United States coastal waters. Over the past decade, the appearance of papillomavirus-induced lesions and viral papillomatosis in manatees has been a concern for those involved in the management and rehabilitation of this species. To date, three manatee papillomaviruses (TmPVs) have been identified in Florida manatees, one forming cutaneous lesions (TmPV1) and two forming genital lesions (TmPV3 and TmPV4). We identified DNA sequences with the potential to form G-quadruplex structures (G4) across the three genomes. G4 were located on both DNA strands and across coding and non-coding regions on all TmPVs, offering multiple targets for viral control. Although G4 have been identified in several viral genomes, including human PVs, most research has focused on canonical structures comprised of three G-tetrads. In contrast, the vast majority of sequences we identified would allow the formation of non-canonical structures with only two G-tetrads. Our biophysical analysis confirmed the formation of G4 with parallel topology in three such sequences from the E2 region. Two of the structures appear comprised of multiple stacked two G-tetrad structures, perhaps serving to increase structural stability. Computational analysis demonstrated enrichment of G4 sequences on all TmPVs on the reverse strand in the E2/E4 region and on both strands in the L2 region. Several G4 sequences occurred at similar regional locations on all PVs, most notably on the reverse strand in the E2 region. In other cases, G4 were identified at similar regional locations only on PVs forming genital lesions. On all TmPVs, G4 sequences were located in the non-coding region near putative E2 binding sites. Together, these findings suggest that G4 are possible regulatory elements in TmPVs." @default.
• W2951488903 created "2019-06-27" @default.
• W2951488903 creator A5004574073 @default.
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• W2951488903 creator A5084059480 @default.
• W2951488903 creator A5091302158 @default.
• W2951488903 date "2018-04-09" @default.
• W2951488903 modified "2023-10-11" @default.
• W2951488903 title "Identification of G-quadruplex forming sequences in three manatee papillomaviruses" @default.
• W2951488903 cites W1450574606 @default.
• W2951488903 cites W1484468867 @default.
• W2951488903 cites W1637420452 @default.
• W2951488903 cites W1862469243 @default.
• W2951488903 cites W1964335041 @default.
• W2951488903 cites W1969089197 @default.
• W2951488903 cites W1974800636 @default.
• W2951488903 cites W1975690779 @default.
• W2951488903 cites W1977305809 @default.
• W2951488903 cites W1981888951 @default.
• W2951488903 cites W1985970608 @default.
• W2951488903 cites W1989920629 @default.
• W2951488903 cites W2005281689 @default.
• W2951488903 cites W2005748917 @default.
• W2951488903 cites W2011398844 @default.
• W2951488903 cites W2012768611 @default.
• W2951488903 cites W2013646237 @default.
• W2951488903 cites W2015736211 @default.
• W2951488903 cites W2020544327 @default.
• W2951488903 cites W2020652742 @default.
• W2951488903 cites W2021191052 @default.
• W2951488903 cites W2022655175 @default.
• W2951488903 cites W2025232009 @default.
• W2951488903 cites W2025811126 @default.
• W2951488903 cites W2027657574 @default.
• W2951488903 cites W2028316542 @default.
• W2951488903 cites W2028397348 @default.
• W2951488903 cites W2029098497 @default.
• W2951488903 cites W2032698727 @default.
• W2951488903 cites W2038263678 @default.
• W2951488903 cites W2038304204 @default.
• W2951488903 cites W2039658297 @default.
• W2951488903 cites W2041361683 @default.
• W2951488903 cites W2049774575 @default.
• W2951488903 cites W2050913592 @default.
• W2951488903 cites W2053445583 @default.
• W2951488903 cites W2055332649 @default.
• W2951488903 cites W2058622161 @default.
• W2951488903 cites W2059306569 @default.
• W2951488903 cites W2060142234 @default.
• W2951488903 cites W2062884167 @default.
• W2951488903 cites W2069961460 @default.
• W2951488903 cites W2072558471 @default.
• W2951488903 cites W2075316517 @default.
• W2951488903 cites W2084038454 @default.
• W2951488903 cites W2084491844 @default.
• W2951488903 cites W2091300209 @default.
• W2951488903 cites W2094832867 @default.
• W2951488903 cites W2100493498 @default.
• W2951488903 cites W2102666141 @default.
• W2951488903 cites W2106154787 @default.
• W2951488903 cites W2107255195 @default.
• W2951488903 cites W2107779830 @default.
• W2951488903 cites W2121672013 @default.
• W2951488903 cites W2123309561 @default.
• W2951488903 cites W2130245511 @default.
• W2951488903 cites W2136163835 @default.
• W2951488903 cites W2143583668 @default.
• W2951488903 cites W2143631627 @default.
• W2951488903 cites W2155697264 @default.
• W2951488903 cites W2156206373 @default.
• W2951488903 cites W2159128272 @default.
• W2951488903 cites W2169745877 @default.
• W2951488903 cites W2171830519 @default.
• W2951488903 cites W2172060739 @default.
• W2951488903 cites W2275411324 @default.
• W2951488903 cites W2288243207 @default.
• W2951488903 cites W2318666519 @default.
• W2951488903 cites W2320172077 @default.
• W2951488903 cites W2320293038 @default.
• W2951488903 cites W2322577116 @default.
• W2951488903 cites W2327269273 @default.
• W2951488903 cites W2331682169 @default.
• W2951488903 cites W2409818225 @default.
• W2951488903 cites W2418801637 @default.
• W2951488903 cites W2514793060 @default.
• W2951488903 cites W2518362417 @default.
• W2951488903 cites W2519514214 @default.
• W2951488903 cites W2535847981 @default.
• W2951488903 cites W2616255601 @default.

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