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- W2951492955 abstract "Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies." @default.
- W2951492955 created "2019-06-27" @default.
- W2951492955 creator A5002819180 @default.
- W2951492955 creator A5004470429 @default.
- W2951492955 creator A5028859733 @default.
- W2951492955 creator A5056755045 @default.
- W2951492955 creator A5067493083 @default.
- W2951492955 creator A5072231950 @default.
- W2951492955 date "2019-06-11" @default.
- W2951492955 modified "2023-10-18" @default.
- W2951492955 title "Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies" @default.
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