Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951503792> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2951503792 endingPage "1073" @default.
- W2951503792 startingPage "1073" @default.
- W2951503792 abstract "Background: The development of inflammation is accompanied by a change in the rheology of the blood - an increase in viscosity, aggregation, a decrease in the osmotic resistance of red blood cells, which indicates a change in the structure of their membrane. This leads to a change in the functional properties of red blood cells and impaired microcirculation. The search for new anti-inflammatory drugs, devoid of side effects is relevant. Promising may be endogenous regulatory peptides of the glyproline family, which have a prophylactic and therapeutic effect in various pathological conditions. Aims: The aim of this study was to investigate changes in the osmotic resistance of erythrocytes in the dynamics of experimental peritonitis with the introduction of the peptide Pro-Gly-Pro (PGP). Methods: A pro-inflammatory agent was used to simulate experimental peritonitis - 40% sodium thioglyaolate solution 4 g/kg, administered intraperitoneally. The erythrocyte osmotic resistance (ORE) was determined 30 minutes, 2 and 18 hours after the induction of inflammation. The evaluation of the wholesale electricity market was carried out to determine the degree of hemolysis in hypotonic solutions of sodium chloride. The light transmittance was recorded on a photoelectrocalorimeter at a wavelength of 580 nm. All experiments were performed in accordance with the ethical principles and regulatory documents recommended by the ESF and the declaration of a humane attitude towards animals. Results: The development of inflammation is accompanied by a decrease in the osmotic resistance of erythrocytes. Statistically significant differences in the wholesale electricity market from control were observed 2 hours after the administration of the thioglycolate. The introduction of PGP peptide at a dose of 3.7 μm/kg before the induction of inflammation reduced pathological changes in the ORE. The percentage of hemolyzed cells decreased, the differences were significant in solutions with salt content of 0.4% and 0.3%. The peptide, introduced against the background of developed inflammation (1 hour and 45 minutes after the introduction of thioglycolate) did not have a corrective effect on the ORE. Summary/Conclusion: The results indicate the ability of PGP to exert a preventive protective effect on the erythrocyte membrane, preventing a decrease in the ORE." @default.
- W2951503792 created "2019-06-27" @default.
- W2951503792 creator A5013904042 @default.
- W2951503792 creator A5072729790 @default.
- W2951503792 creator A5078328350 @default.
- W2951503792 date "2019-06-01" @default.
- W2951503792 modified "2023-10-18" @default.
- W2951503792 title "PB2419 PEPTIDE CORRECTION OF OSMOTIC RESISTANCE DISORDERS IN INFLAMMATION" @default.
- W2951503792 doi "https://doi.org/10.1097/01.hs9.0000568140.30893.00" @default.
- W2951503792 hasPublicationYear "2019" @default.
- W2951503792 type Work @default.
- W2951503792 sameAs 2951503792 @default.
- W2951503792 citedByCount "0" @default.
- W2951503792 crossrefType "journal-article" @default.
- W2951503792 hasAuthorship W2951503792A5013904042 @default.
- W2951503792 hasAuthorship W2951503792A5072729790 @default.
- W2951503792 hasAuthorship W2951503792A5078328350 @default.
- W2951503792 hasBestOaLocation W29515037921 @default.
- W2951503792 hasConcept C126322002 @default.
- W2951503792 hasConcept C12722491 @default.
- W2951503792 hasConcept C178790620 @default.
- W2951503792 hasConcept C185592680 @default.
- W2951503792 hasConcept C2776914184 @default.
- W2951503792 hasConcept C2777426075 @default.
- W2951503792 hasConcept C2779902561 @default.
- W2951503792 hasConcept C2780199535 @default.
- W2951503792 hasConcept C2780959883 @default.
- W2951503792 hasConcept C2994203641 @default.
- W2951503792 hasConcept C537181965 @default.
- W2951503792 hasConcept C55493867 @default.
- W2951503792 hasConcept C71924100 @default.
- W2951503792 hasConcept C9603476 @default.
- W2951503792 hasConcept C98274493 @default.
- W2951503792 hasConceptScore W2951503792C126322002 @default.
- W2951503792 hasConceptScore W2951503792C12722491 @default.
- W2951503792 hasConceptScore W2951503792C178790620 @default.
- W2951503792 hasConceptScore W2951503792C185592680 @default.
- W2951503792 hasConceptScore W2951503792C2776914184 @default.
- W2951503792 hasConceptScore W2951503792C2777426075 @default.
- W2951503792 hasConceptScore W2951503792C2779902561 @default.
- W2951503792 hasConceptScore W2951503792C2780199535 @default.
- W2951503792 hasConceptScore W2951503792C2780959883 @default.
- W2951503792 hasConceptScore W2951503792C2994203641 @default.
- W2951503792 hasConceptScore W2951503792C537181965 @default.
- W2951503792 hasConceptScore W2951503792C55493867 @default.
- W2951503792 hasConceptScore W2951503792C71924100 @default.
- W2951503792 hasConceptScore W2951503792C9603476 @default.
- W2951503792 hasConceptScore W2951503792C98274493 @default.
- W2951503792 hasIssue "S1" @default.
- W2951503792 hasLocation W29515037921 @default.
- W2951503792 hasLocation W29515037922 @default.
- W2951503792 hasOpenAccess W2951503792 @default.
- W2951503792 hasPrimaryLocation W29515037921 @default.
- W2951503792 hasRelatedWork W1677686864 @default.
- W2951503792 hasRelatedWork W1930417714 @default.
- W2951503792 hasRelatedWork W2051925123 @default.
- W2951503792 hasRelatedWork W2397921543 @default.
- W2951503792 hasRelatedWork W2399547661 @default.
- W2951503792 hasRelatedWork W2401302815 @default.
- W2951503792 hasRelatedWork W2401429538 @default.
- W2951503792 hasRelatedWork W3122844591 @default.
- W2951503792 hasRelatedWork W4320399512 @default.
- W2951503792 hasRelatedWork W1487702449 @default.
- W2951503792 hasVolume "3" @default.
- W2951503792 isParatext "false" @default.
- W2951503792 isRetracted "false" @default.
- W2951503792 magId "2951503792" @default.
- W2951503792 workType "article" @default.