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• W2951514483 endingPage "175909141985681" @default.
• W2951514483 startingPage "175909141985681" @default.
• W2951514483 abstract "Huntington’s disease (HD) is a neurodegenerative autosomal dominant disorder, characterized by symptoms of involuntary movement of the body, loss of cognitive function, psychiatric disorder, leading inevitably to death. It has been previously described that higher levels of brain expression of Ca v 1 channels are involved in major neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Our results demonstrate that a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD mice) at the age of 3 and 12 months exhibits significantly increased Ca v 1.2 protein levels in the cortex, as compared with wild-type littermates. Importantly, electrophysiological analyses confirm a significant increase in L-type Ca 2+ currents and total Ca 2+ current density in cortical neurons from BACHD mice. By using an in vitro assay to measure neuronal cell death, we were able to observe neuronal protection against glutamate toxicity after treatment with Ca v 1 blockers, in wild-type and, more importantly, in BACHD neurons. According to our data, Ca v 1 blockers may offer an interesting strategy for the treatment of HD. Altogether, our results show that mutant huntingtin (mHtt) expression may cause a dysregulation of Ca v 1.2 channels and we hypothesize that this contributes to neurodegeneration during HD." @default.
• W2951514483 created "2019-06-27" @default.
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• W2951514483 date "2019-01-01" @default.
• W2951514483 modified "2023-10-14" @default.
• W2951514483 title "Alterations of Calcium Channels in a Mouse Model of Huntington’s Disease and Neuroprotection by Blockage of Ca_V1 Channels" @default.
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• W2951514483 doi "https://doi.org/10.1177/1759091419856811" @default.
• W2951514483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6585245" @default.
• W2951514483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31216184" @default.
• W2951514483 hasPublicationYear "2019" @default.
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