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- W2951531132 abstract "Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted quinazolinones 5 posses a significant antiproliferative activity, with a percentage growth inhibition ranging from 44.8% to 100% at 50 microM, which was higher than that showed by the unsubstituted derivative 5a previously synthesized. For the most active compounds 5d, 5f, and 5g the IC50 were recorded." @default.
- W2951531132 created "2019-06-27" @default.
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- W2951531132 date "2010-06-12" @default.
- W2951531132 modified "2023-09-25" @default.
- W2951531132 title "ChemInform Abstract: Synthesis and Antiproliferative Activity of Novel 3-(Indazol-3-yl)-quinazolin-4(3H)-one and 3-(Indazol-3-yl)-benzotriazin-4(3H)-one Derivatives." @default.
- W2951531132 cites W2004429189 @default.
- W2951531132 doi "https://doi.org/10.1002/chin.199949208" @default.
- W2951531132 hasPublicationYear "2010" @default.
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