FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951531839> ?p ?o ?g. }

• W2951531839 endingPage "505" @default.
• W2951531839 startingPage "497" @default.
• W2951531839 abstract "Abstract Motivation Recent years have witnessed an exponential growth in the number of identified interactions between biological molecules. These interactions are usually represented as large and complex networks, calling for the development of appropriated tools to exploit the functional information they contain. Random walk with restart (RWR) is the state-of-the-art guilt-by-association approach. It explores the network vicinity of gene/protein seeds to study their functions, based on the premise that nodes related to similar functions tend to lie close to each other in the networks. Results In this study, we extended the RWR algorithm to multiplex and heterogeneous networks. The walk can now explore different layers of physical and functional interactions between genes and proteins, such as protein–protein interactions and co-expression associations. In addition, the walk can also jump to a network containing different sets of edges and nodes, such as phenotype similarities between diseases. We devised a leave-one-out cross-validation strategy to evaluate the algorithms abilities to predict disease-associated genes. We demonstrate the increased performances of the multiplex-heterogeneous RWR as compared to several random walks on monoplex or heterogeneous networks. Overall, our framework is able to leverage the different interaction sources to outperform current approaches. Finally, we applied the algorithm to predict candidate genes for the Wiedemann–Rautenstrauch syndrome, and to explore the network vicinity of the SHORT syndrome. Availability and implementation The source code is available on GitHub at: https://github.com/alberto-valdeolivas/RWR-MH. In addition, an R package is freely available through Bioconductor at: http://bioconductor.org/packages/RandomWalkRestartMH/. Supplementary information Supplementary data are available at Bioinformatics online." @default.
• W2951531839 created "2019-06-27" @default.
• W2951531839 creator A5003165072 @default.
• W2951531839 creator A5055320854 @default.
• W2951531839 creator A5060810847 @default.
• W2951531839 creator A5062724732 @default.
• W2951531839 creator A5064788033 @default.
• W2951531839 creator A5065507596 @default.
• W2951531839 creator A5074298045 @default.
• W2951531839 creator A5080878366 @default.
• W2951531839 creator A5082003101 @default.
• W2951531839 date "2018-07-18" @default.
• W2951531839 modified "2023-10-11" @default.
• W2951531839 title "Random walk with restart on multiplex and heterogeneous biological networks" @default.
• W2951531839 cites W1486817521 @default.
• W2951531839 cites W1783384641 @default.
• W2951531839 cites W1792797861 @default.
• W2951531839 cites W1807089695 @default.
• W2951531839 cites W1973872989 @default.
• W2951531839 cites W1978908220 @default.
• W2951531839 cites W1981302634 @default.
• W2951531839 cites W1982774551 @default.
• W2951531839 cites W1983226769 @default.
• W2951531839 cites W1989277387 @default.
• W2951531839 cites W2005980089 @default.
• W2951531839 cites W2014478203 @default.
• W2951531839 cites W2020301095 @default.
• W2951531839 cites W2020755434 @default.
• W2951531839 cites W2038122249 @default.
• W2951531839 cites W2045949302 @default.
• W2951531839 cites W2056782561 @default.
• W2951531839 cites W2062089569 @default.
• W2951531839 cites W2066636486 @default.
• W2951531839 cites W2070412833 @default.
• W2951531839 cites W2072461465 @default.
• W2951531839 cites W2086243891 @default.
• W2951531839 cites W2100251770 @default.
• W2951531839 cites W2100582962 @default.
• W2951531839 cites W2102839669 @default.
• W2951531839 cites W2103017472 @default.
• W2951531839 cites W2104622981 @default.
• W2951531839 cites W2112016110 @default.
• W2951531839 cites W2112928309 @default.
• W2951531839 cites W2118607021 @default.
• W2951531839 cites W2119220491 @default.
• W2951531839 cites W2119412782 @default.
• W2951531839 cites W2123060905 @default.
• W2951531839 cites W2130948051 @default.
• W2951531839 cites W2143943364 @default.
• W2951531839 cites W2147575850 @default.
• W2951531839 cites W2148043260 @default.
• W2951531839 cites W2150619381 @default.
• W2951531839 cites W2154654747 @default.
• W2951531839 cites W2159675211 @default.
• W2951531839 cites W2160390633 @default.
• W2951531839 cites W2170282111 @default.
• W2951531839 cites W2196880011 @default.
• W2951531839 cites W2261598201 @default.
• W2951531839 cites W2537679995 @default.
• W2951531839 cites W3037826211 @default.
• W2951531839 cites W434524946 @default.
• W2951531839 doi "https://doi.org/10.1093/bioinformatics/bty637" @default.
• W2951531839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30020411" @default.
• W2951531839 hasPublicationYear "2018" @default.
• W2951531839 type Work @default.
• W2951531839 sameAs 2951531839 @default.
• W2951531839 citedByCount "151" @default.
• W2951531839 countsByYear W29515318392018 @default.
• W2951531839 countsByYear W29515318392019 @default.
• W2951531839 countsByYear W29515318392020 @default.
• W2951531839 countsByYear W29515318392021 @default.
• W2951531839 countsByYear W29515318392022 @default.
• W2951531839 countsByYear W29515318392023 @default.
• W2951531839 crossrefType "journal-article" @default.
• W2951531839 hasAuthorship W2951531839A5003165072 @default.
• W2951531839 hasAuthorship W2951531839A5055320854 @default.
• W2951531839 hasAuthorship W2951531839A5060810847 @default.
• W2951531839 hasAuthorship W2951531839A5062724732 @default.
• W2951531839 hasAuthorship W2951531839A5064788033 @default.
• W2951531839 hasAuthorship W2951531839A5065507596 @default.
• W2951531839 hasAuthorship W2951531839A5074298045 @default.
• W2951531839 hasAuthorship W2951531839A5080878366 @default.
• W2951531839 hasAuthorship W2951531839A5082003101 @default.
• W2951531839 hasBestOaLocation W29515318391 @default.
• W2951531839 hasConcept C105795698 @default.
• W2951531839 hasConcept C111919701 @default.
• W2951531839 hasConcept C121194460 @default.
• W2951531839 hasConcept C153083717 @default.
• W2951531839 hasConcept C154945302 @default.
• W2951531839 hasConcept C165696696 @default.
• W2951531839 hasConcept C2781188995 @default.
• W2951531839 hasConcept C28225019 @default.
• W2951531839 hasConcept C2984074130 @default.
• W2951531839 hasConcept C33923547 @default.
• W2951531839 hasConcept C38652104 @default.
• W2951531839 hasConcept C41008148 @default.
• W2951531839 hasConcept C43126263 @default.
• W2951531839 hasConcept C459310 @default.

• next