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- W2951532554 abstract "Abstract TLRs respond to a variety of microbial products and initiate defense responses against bacteria and viruses. A variety of pathogens invade into and control the endosomal compartment to survive in host cells. On the other hand, host cells deploy cell surface and endosomal TLRs to pathogen-containing vesicles to mount defense responses. The endosomal compartment is a site for pathogen-sensing. As TLR-dependent defense responses are accompanied with a shift to the anabolic state, TLR responses need to be under metabolic control. Cellular metabolic state is monitored by sensing lysosomal metabolites by the mammalian target of rapamycin complex 1 (mTORC1). Type I IFN production induced by endosomal TLRs requires mTORC1. Recent studies have demonstrated that the interaction between TLRs and mTORC1 depends on their anterograde movement to the cell periphery. In a nutrient-sufficient state, a molecular complex called Ragulator recruits and activates mTORC1 in lysosomes. In parallel, Ragulator allows the small GTPase Arl8b to drive lysosomes to the cell periphery. Nutrient-activated mTORC1 in peripheral lysosomes is constitutively associated with type I IFN signaling molecules such as TRAF3 and IKKα. On the other hand, TLR7 and TLR3 are activated in the endosomal compartment and induce trafficking of TLR-containing vesicles to the cell periphery in a manner dependent on Arl8b or another GTPase Rab7a, respectively. Lysosomal trafficking helps TLR7 and TLR3 to interact with nutrient-activated mTORC1 and type I IFN signaling molecules. The endosomal compartments serve as platforms where metabolic sensing machinery licenses TLRs to initiate type I IFN responses." @default.
- W2951532554 created "2019-06-27" @default.
- W2951532554 creator A5012613096 @default.
- W2951532554 creator A5037069729 @default.
- W2951532554 creator A5045382494 @default.
- W2951532554 creator A5065401658 @default.
- W2951532554 creator A5080600650 @default.
- W2951532554 creator A5089115794 @default.
- W2951532554 date "2019-06-20" @default.
- W2951532554 modified "2023-09-25" @default.
- W2951532554 title "Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors" @default.
- W2951532554 cites W1519329230 @default.
- W2951532554 cites W1537388372 @default.
- W2951532554 cites W1576065803 @default.
- W2951532554 cites W1577102950 @default.
- W2951532554 cites W1631384870 @default.
- W2951532554 cites W1738782024 @default.
- W2951532554 cites W1964168671 @default.
- W2951532554 cites W1975686298 @default.
- W2951532554 cites W1977039417 @default.
- W2951532554 cites W1981206208 @default.
- W2951532554 cites W1982219839 @default.
- W2951532554 cites W1993211211 @default.
- W2951532554 cites W1997977259 @default.
- W2951532554 cites W1999286245 @default.
- W2951532554 cites W2001166572 @default.
- W2951532554 cites W2007427970 @default.
- W2951532554 cites W2010498205 @default.
- W2951532554 cites W2011678998 @default.
- W2951532554 cites W2019676172 @default.
- W2951532554 cites W2020920210 @default.
- W2951532554 cites W2031113436 @default.
- W2951532554 cites W2032639905 @default.
- W2951532554 cites W2038554653 @default.
- W2951532554 cites W2052309340 @default.
- W2951532554 cites W2052521175 @default.
- W2951532554 cites W2054828149 @default.
- W2951532554 cites W2056137479 @default.
- W2951532554 cites W2060607801 @default.
- W2951532554 cites W2062025882 @default.
- W2951532554 cites W2066736950 @default.
- W2951532554 cites W2067678108 @default.
- W2951532554 cites W2069663822 @default.
- W2951532554 cites W2078604791 @default.
- W2951532554 cites W2078765043 @default.
- W2951532554 cites W2086676026 @default.
- W2951532554 cites W2088768592 @default.
- W2951532554 cites W2093154482 @default.
- W2951532554 cites W2094045593 @default.
- W2951532554 cites W2094941596 @default.
- W2951532554 cites W2095235563 @default.
- W2951532554 cites W2107315506 @default.
- W2951532554 cites W2107406729 @default.
- W2951532554 cites W2110719003 @default.
- W2951532554 cites W2110909388 @default.
- W2951532554 cites W2111428445 @default.
- W2951532554 cites W2111922856 @default.
- W2951532554 cites W2113295282 @default.
- W2951532554 cites W2117002197 @default.
- W2951532554 cites W2127088485 @default.
- W2951532554 cites W2127934565 @default.
- W2951532554 cites W2134847649 @default.
- W2951532554 cites W2141753982 @default.
- W2951532554 cites W2147763501 @default.
- W2951532554 cites W2153607816 @default.
- W2951532554 cites W2156469236 @default.
- W2951532554 cites W2160757449 @default.
- W2951532554 cites W2160775559 @default.
- W2951532554 cites W2166386800 @default.
- W2951532554 cites W2166990341 @default.
- W2951532554 cites W2167276755 @default.
- W2951532554 cites W2169721017 @default.
- W2951532554 cites W2192238419 @default.
- W2951532554 cites W2210729715 @default.
- W2951532554 cites W2286309596 @default.
- W2951532554 cites W2289411371 @default.
- W2951532554 cites W2297241277 @default.
- W2951532554 cites W2321198083 @default.
- W2951532554 cites W2409988635 @default.
- W2951532554 cites W2530273804 @default.
- W2951532554 cites W2532819072 @default.
- W2951532554 cites W2552061884 @default.
- W2951532554 cites W2583725498 @default.
- W2951532554 cites W2591477152 @default.
- W2951532554 cites W2593816418 @default.
- W2951532554 cites W2603101815 @default.
- W2951532554 cites W2603916465 @default.
- W2951532554 cites W2612560775 @default.
- W2951532554 cites W2622166486 @default.
- W2951532554 cites W2754680796 @default.
- W2951532554 cites W2761865861 @default.
- W2951532554 cites W2768124112 @default.
- W2951532554 cites W2769592732 @default.
- W2951532554 cites W2773300145 @default.
- W2951532554 cites W2792612262 @default.
- W2951532554 cites W2808041642 @default.
- W2951532554 cites W2883789999 @default.
- W2951532554 cites W2889979805 @default.