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- W2951566043 abstract "The generation of spiking resonances in neurons (preferred spiking responses to oscillatory inputs) requires the interplay of the intrinsic ionic currents that operate at the subthreshold voltage level and the spiking mechanisms. Combinations of the same types of ionic currents in different parameter regimes may give rise to different types of nonlinearities in the voltage equation (e.g., parabolic- and cubic-like), generating subthreshold (membrane potential) oscillations patterns with different properties. These nonlinearities are not apparent in the model equations, but can be uncovered by plotting the voltage nullclines in the phase-plane diagram. We investigate the spiking resonant properties of conductance-based models that are biophysically equivalent at the subthreshold level (same ionic currents), but dynamically different (parabolic- and cubic-like voltage nullclines). As a case study we consider a model having a persistent sodium and a hyperpolarization-activated (h-) currents, which exhibits subthreshold resonance in the theta frequency band. We unfold the concept of spiking resonance into evoked and output spiking resonance. The former focuses on the input frequencies that are able to generate spikes, while the latter focuses on the output spiking frequencies regardless of the input frequency that generated these spikes. A cell can exhibit one or both types of resonances. We also measure spiking phasonance, which is an extension of subthreshold phasonance (zero-phase-shift response to oscillatory inputs) to the spiking regime. The subthreshold resonant properties of both types of models are communicated to the spiking regime for low enough input amplitudes as the voltage response for the subthreshold resonant frequency band raises above threshold. For higher input amplitudes evoked spiking resonance is no longer present in these models, but output spiking resonance is present primarily in the parabolic-like model due to a cycle skipping mechanism (involving mixed-mode oscillations), while the cubic-like model shows a better 1:1 entrainment. We use dynamical systems tools to explain the underlying mechanisms and the mechanistic differences between the resonance types. Our results demonstrate that the effective time scales that operate at the subthreshold regime to generate intrinsic subthreshold oscillations, mixed-mode oscillations and subthreshold resonance do not necessarily determine the existence of a preferred spiking response to oscillatory inputs in the same frequency band. The results discussed in this paper highlight both the complexity of the suprathreshold responses to oscillatory inputs in neurons having resonant and amplifying currents with different time scales and the fact that the identity of the participating ionic currents is not enough to predict the resulting patterns, but additional dynamic information, captured by the geometric properties of the phase-space diagram, is needed." @default.
- W2951566043 created "2019-06-27" @default.
- W2951566043 creator A5046627918 @default.
- W2951566043 date "2017-10-24" @default.
- W2951566043 modified "2023-10-15" @default.
- W2951566043 title "Spiking resonances in models with the same slow resonant and fast amplifying currents but different subthreshold dynamic properties" @default.
- W2951566043 cites W1185063720 @default.
- W2951566043 cites W1480219974 @default.
- W2951566043 cites W1525542820 @default.
- W2951566043 cites W1548653509 @default.
- W2951566043 cites W1576838367 @default.
- W2951566043 cites W1597876830 @default.
- W2951566043 cites W1911320126 @default.
- W2951566043 cites W1918906452 @default.
- W2951566043 cites W1965881120 @default.
- W2951566043 cites W1966422754 @default.
- W2951566043 cites W1966473354 @default.
- W2951566043 cites W1970510328 @default.
- W2951566043 cites W1977181457 @default.
- W2951566043 cites W1981855363 @default.
- W2951566043 cites W1982713952 @default.
- W2951566043 cites W1985940938 @default.
- W2951566043 cites W1991074008 @default.
- W2951566043 cites W2002602970 @default.
- W2951566043 cites W2006902614 @default.
- W2951566043 cites W2009375605 @default.
- W2951566043 cites W2011819349 @default.
- W2951566043 cites W2012082631 @default.
- W2951566043 cites W2012217824 @default.
- W2951566043 cites W2017855292 @default.
- W2951566043 cites W2023925279 @default.
- W2951566043 cites W2024275179 @default.
- W2951566043 cites W2030033817 @default.
- W2951566043 cites W2030253159 @default.
- W2951566043 cites W2034307400 @default.
- W2951566043 cites W2043325561 @default.
- W2951566043 cites W2045348258 @default.
- W2951566043 cites W2045839462 @default.
- W2951566043 cites W2047863847 @default.
- W2951566043 cites W2050705601 @default.
- W2951566043 cites W2056833737 @default.
- W2951566043 cites W2057187045 @default.
- W2951566043 cites W2058237783 @default.
- W2951566043 cites W2059552278 @default.
- W2951566043 cites W2060245582 @default.
- W2951566043 cites W2061135970 @default.
- W2951566043 cites W2061191702 @default.
- W2951566043 cites W2062029765 @default.
- W2951566043 cites W2062633392 @default.
- W2951566043 cites W2064539980 @default.
- W2951566043 cites W2078401986 @default.
- W2951566043 cites W2081131230 @default.
- W2951566043 cites W2084355543 @default.
- W2951566043 cites W2084913706 @default.
- W2951566043 cites W2088358935 @default.
- W2951566043 cites W2088576296 @default.
- W2951566043 cites W2089995439 @default.
- W2951566043 cites W2091770488 @default.
- W2951566043 cites W2091883322 @default.
- W2951566043 cites W2095436582 @default.
- W2951566043 cites W2097450763 @default.
- W2951566043 cites W2104892692 @default.
- W2951566043 cites W2108184772 @default.
- W2951566043 cites W2112666468 @default.
- W2951566043 cites W2114863659 @default.
- W2951566043 cites W2120284757 @default.
- W2951566043 cites W2123746357 @default.
- W2951566043 cites W2126007099 @default.
- W2951566043 cites W2126211141 @default.
- W2951566043 cites W2126742861 @default.
- W2951566043 cites W2127568004 @default.
- W2951566043 cites W2131720818 @default.
- W2951566043 cites W2139413555 @default.
- W2951566043 cites W2144067591 @default.
- W2951566043 cites W2144536052 @default.
- W2951566043 cites W2145180114 @default.
- W2951566043 cites W2145592553 @default.
- W2951566043 cites W2146619218 @default.
- W2951566043 cites W2152982331 @default.
- W2951566043 cites W2153904027 @default.
- W2951566043 cites W2155998803 @default.
- W2951566043 cites W2156075637 @default.
- W2951566043 cites W2159723961 @default.
- W2951566043 cites W2162445001 @default.
- W2951566043 cites W2163071226 @default.
- W2951566043 cites W2163493491 @default.
- W2951566043 cites W2168295097 @default.
- W2951566043 cites W2169345222 @default.
- W2951566043 cites W2173355496 @default.
- W2951566043 cites W2326772754 @default.
- W2951566043 cites W2343821877 @default.
- W2951566043 cites W2475271757 @default.
- W2951566043 cites W2475765891 @default.
- W2951566043 cites W2551432261 @default.
- W2951566043 cites W2558216909 @default.
- W2951566043 cites W2950487668 @default.
- W2951566043 cites W2953244756 @default.
- W2951566043 cites W316919195 @default.