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- W2951567297 abstract "Direct cellular reprogramming provides a powerful platform to study cell plasticity and dissect mechanisms underlying cell fate determination. Here, we report a single-cell transcriptomic study of human cardiac (hiCM) reprogramming that utilizes an analysis pipeline incorporating current data normalization methods, multiple trajectory prediction algorithms, and a cell fate index calculation we developed to measure reprogramming progression. These analyses revealed hiCM reprogramming-specific features and a decision point at which cells either embark on reprogramming or regress toward their original fibroblast state. In combination with functional screening, we found that immune-response-associated DNA methylation is required for hiCM induction and validated several downstream targets of reprogramming factors as necessary for productive hiCM reprograming. Collectively, this single-cell transcriptomics study provides detailed datasets that reveal molecular features underlying hiCM determination and rigorous analytical pipelines for predicting cell fate conversion." @default.
- W2951567297 created "2019-06-27" @default.
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- W2951567297 date "2019-07-01" @default.
- W2951567297 modified "2023-10-17" @default.
- W2951567297 title "Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming" @default.
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- W2951567297 doi "https://doi.org/10.1016/j.stem.2019.05.020" @default.
- W2951567297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6684137" @default.
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