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• W2951570657 abstract "Abstract We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([ EC 50 ]), and effective Hill coefficient, and explore the full spectrum of phenotypes that are accessible through mutations. Specifically, we consider mutations in the channel pore of nicotinic acetylcholine receptor (nAChR) and the ligand binding domain of a cyclic nucleotide-gated (CNG) ion channel, demonstrating how each mutation can be characterized as only affecting a subset of the biophysical parameters. In addition, we show how the unifying perspective offered by the MWC model allows us, perhaps surprisingly, to collapse the plethora of dose-response data from different classes of ion channels into a universal family of curves." @default.
• W2951570657 created "2019-06-27" @default.
• W2951570657 creator A5015900117 @default.
• W2951570657 creator A5029612834 @default.
• W2951570657 date "2017-01-22" @default.
• W2951570657 modified "2023-09-25" @default.
• W2951570657 title "Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants" @default.
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• W2951570657 doi "https://doi.org/10.1101/102194" @default.
• W2951570657 hasPublicationYear "2017" @default.
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