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- W2951581738 endingPage "596" @default.
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- W2951581738 abstract "Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This ‘experiment of nature’ reflects the critical role of IGF1 in tumor biology. The present review article provides an overview of recently conducted genome-wide profiling analyses aimed at identifying mechanisms and signaling pathways that are directly responsible for the link between life-time low IGF1 levels and protection from tumor development. The review underscores the concept that ‘data mining’ an orphan disease might translate into new developments in oncology." @default.
- W2951581738 created "2019-06-27" @default.
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- W2951581738 date "2019-06-15" @default.
- W2951581738 modified "2023-09-27" @default.
- W2951581738 title "Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways" @default.
- W2951581738 cites W102166461 @default.
- W2951581738 cites W1187437754 @default.
- W2951581738 cites W1534366901 @default.
- W2951581738 cites W1966980638 @default.
- W2951581738 cites W1970332601 @default.
- W2951581738 cites W1970563875 @default.
- W2951581738 cites W1972255467 @default.
- W2951581738 cites W1974196575 @default.
- W2951581738 cites W1985594739 @default.
- W2951581738 cites W1990430867 @default.
- W2951581738 cites W1994212409 @default.
- W2951581738 cites W1997112179 @default.
- W2951581738 cites W2004170579 @default.
- W2951581738 cites W2010710724 @default.
- W2951581738 cites W2013578615 @default.
- W2951581738 cites W2017536128 @default.
- W2951581738 cites W2019685965 @default.
- W2951581738 cites W2020636054 @default.
- W2951581738 cites W2025651276 @default.
- W2951581738 cites W2043131574 @default.
- W2951581738 cites W2044972168 @default.
- W2951581738 cites W2050853712 @default.
- W2951581738 cites W2053736563 @default.
- W2951581738 cites W2054458373 @default.
- W2951581738 cites W2060033992 @default.
- W2951581738 cites W2061477949 @default.
- W2951581738 cites W2065433570 @default.
- W2951581738 cites W2067233601 @default.
- W2951581738 cites W2071910975 @default.
- W2951581738 cites W2072782054 @default.
- W2951581738 cites W2073287644 @default.
- W2951581738 cites W2073454559 @default.
- W2951581738 cites W2079137397 @default.
- W2951581738 cites W2079373283 @default.
- W2951581738 cites W2079886125 @default.
- W2951581738 cites W2083137480 @default.
- W2951581738 cites W2084967524 @default.
- W2951581738 cites W2088879509 @default.
- W2951581738 cites W2089527908 @default.
- W2951581738 cites W2094402452 @default.
- W2951581738 cites W2097502952 @default.
- W2951581738 cites W2102303758 @default.
- W2951581738 cites W2104794017 @default.
- W2951581738 cites W2109600717 @default.
- W2951581738 cites W2111345553 @default.
- W2951581738 cites W2111843196 @default.
- W2951581738 cites W2117350664 @default.
- W2951581738 cites W2121394848 @default.
- W2951581738 cites W2125744480 @default.
- W2951581738 cites W2128962458 @default.
- W2951581738 cites W2129847941 @default.
- W2951581738 cites W2133492435 @default.
- W2951581738 cites W2137560695 @default.
- W2951581738 cites W2144211817 @default.
- W2951581738 cites W2144715185 @default.
- W2951581738 cites W2156136676 @default.
- W2951581738 cites W2162154276 @default.
- W2951581738 cites W2163218223 @default.
- W2951581738 cites W2165638597 @default.
- W2951581738 cites W2169840370 @default.
- W2951581738 cites W2171846843 @default.
- W2951581738 cites W2203091969 @default.
- W2951581738 cites W2274273904 @default.
- W2951581738 cites W2319957376 @default.
- W2951581738 cites W2320296534 @default.
- W2951581738 cites W2336229842 @default.
- W2951581738 cites W2339232764 @default.
- W2951581738 cites W2412722659 @default.
- W2951581738 cites W2413138283 @default.
- W2951581738 cites W2433000869 @default.
- W2951581738 cites W2518219781 @default.
- W2951581738 cites W2592087460 @default.
- W2951581738 cites W2607666115 @default.
- W2951581738 cites W2620603874 @default.
- W2951581738 cites W2713283324 @default.
- W2951581738 cites W2730362172 @default.
- W2951581738 cites W2742474598 @default.
- W2951581738 cites W2747103408 @default.
- W2951581738 cites W2770199474 @default.
- W2951581738 cites W2773203124 @default.
- W2951581738 cites W2778959969 @default.
- W2951581738 cites W2783939587 @default.
- W2951581738 cites W2887505080 @default.