FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951598154> ?p ?o ?g. }

• W2951598154 endingPage "419" @default.
• W2951598154 startingPage "408" @default.
• W2951598154 abstract "The aims of this work were to evaluate whether the treatment of patients with fibromyalgia with memantine is associated with significant changes in metabolite concentrations in the brain, and to explore any changes in clinical outcome measures. Magnetic resonance spectroscopy was performed of the right anterior and posterior insula, both hippocampi and the posterior cingulate cortex. Questionnaires on pain, anxiety, depression, global function, quality of life and cognitive impairment were used. Ten patients were studied at baseline and after three months of treatment with memantine. Significant increases were observed in the following areas: N-acetylaspartate (4.47 at baseline vs. 4.71 at three months, p = 0.02) and N-acetylaspartate+N-acetylaspartate glutamate in the left hippocampus (5.89 vs. 5.98; p = 0.007); N-acetylaspartate+N-acetylaspartate glutamate in the right hippocampus (5.31 vs 5.79; p = 0.01) and the anterior insula (7.56 vs. 7.70; p = 0.033); glutamate+glutamine/creatine ratio in the anterior insula (2.03 vs. 2.17; p = 0.022) and the posterior insula (1.77 vs. 2.00; p = 0.004); choline/creatine ratio in the posterior cingulate (0.18 vs. 0.19; p = 0.023); and creatine in the right hippocampus (3.60 vs. 3.85; p = 0.007). At the three-month follow-up, memantine improved cognitive function assessed by the Cognition Mini-Exam (31.50, SD = 2.95 vs. 34.40, SD = 0.6; p = 0.005), depression measured by the Hamilton Depression Scale (7.70, SD = 0.81 vs. 7.56, SD = 0.68; p = 0.042) and severity of illness measured by the Clinical Global Impression severity scale (5.79, SD = 0.96 vs. 5.31, SD = 1.12; p = 0.007). Depression, clinical global impression and cognitive function showed improvement with memantine. Magnetic resonance spectroscopy could be useful in monitoring response to the pharmacological treatment of fibromyalgia." @default.
• W2951598154 created "2019-06-27" @default.
• W2951598154 creator A5002843753 @default.
• W2951598154 creator A5010556149 @default.
• W2951598154 creator A5014643608 @default.
• W2951598154 creator A5024161160 @default.
• W2951598154 creator A5025849303 @default.
• W2951598154 creator A5036960313 @default.
• W2951598154 creator A5056204278 @default.
• W2951598154 creator A5062296536 @default.
• W2951598154 creator A5066428181 @default.
• W2951598154 creator A5087631127 @default.
• W2951598154 date "2019-06-19" @default.
• W2951598154 modified "2023-10-18" @default.
• W2951598154 title "Changes in metabolites in the brain of patients with fibromyalgia after treatment with an NMDA receptor antagonist" @default.
• W2951598154 cites W117001103 @default.
• W2951598154 cites W1488986653 @default.
• W2951598154 cites W1497484063 @default.
• W2951598154 cites W1500403088 @default.
• W2951598154 cites W1749786054 @default.
• W2951598154 cites W1774387537 @default.
• W2951598154 cites W1870618843 @default.
• W2951598154 cites W1966219326 @default.
• W2951598154 cites W1967791571 @default.
• W2951598154 cites W1971799836 @default.
• W2951598154 cites W1972958276 @default.
• W2951598154 cites W1978097271 @default.
• W2951598154 cites W1978838638 @default.
• W2951598154 cites W1987856010 @default.
• W2951598154 cites W1988931872 @default.
• W2951598154 cites W1990876814 @default.
• W2951598154 cites W1992521533 @default.
• W2951598154 cites W1997576702 @default.
• W2951598154 cites W2003982930 @default.
• W2951598154 cites W2007443551 @default.
• W2951598154 cites W2009928888 @default.
• W2951598154 cites W2013568245 @default.
• W2951598154 cites W2014084349 @default.
• W2951598154 cites W2020648457 @default.
• W2951598154 cites W2023630108 @default.
• W2951598154 cites W2028416381 @default.
• W2951598154 cites W2032867586 @default.
• W2951598154 cites W2038979894 @default.
• W2951598154 cites W2044659838 @default.
• W2951598154 cites W2050892980 @default.
• W2951598154 cites W2056223650 @default.
• W2951598154 cites W2057327829 @default.
• W2951598154 cites W2064202348 @default.
• W2951598154 cites W2064839369 @default.
• W2951598154 cites W2072983646 @default.
• W2951598154 cites W2073040184 @default.
• W2951598154 cites W2075869814 @default.
• W2951598154 cites W2082018974 @default.
• W2951598154 cites W2083198832 @default.
• W2951598154 cites W2091958137 @default.
• W2951598154 cites W2092356280 @default.
• W2951598154 cites W2106665244 @default.
• W2951598154 cites W2108403304 @default.
• W2951598154 cites W2113539308 @default.
• W2951598154 cites W2116146623 @default.
• W2951598154 cites W2116230226 @default.
• W2951598154 cites W2119627481 @default.
• W2951598154 cites W2120887129 @default.
• W2951598154 cites W2126096821 @default.
• W2951598154 cites W2131744811 @default.
• W2951598154 cites W2132806643 @default.
• W2951598154 cites W2135812251 @default.
• W2951598154 cites W2140037651 @default.
• W2951598154 cites W2142823391 @default.
• W2951598154 cites W2145169691 @default.
• W2951598154 cites W2149444223 @default.
• W2951598154 cites W2149862066 @default.
• W2951598154 cites W2150400736 @default.
• W2951598154 cites W2159431069 @default.
• W2951598154 cites W2162134510 @default.
• W2951598154 cites W2163103034 @default.
• W2951598154 cites W2164401288 @default.
• W2951598154 cites W2168950319 @default.
• W2951598154 cites W2176325173 @default.
• W2951598154 cites W2179789499 @default.
• W2951598154 cites W2253364553 @default.
• W2951598154 cites W2334193464 @default.
• W2951598154 cites W2344135956 @default.
• W2951598154 cites W2346744058 @default.
• W2951598154 cites W2396459437 @default.
• W2951598154 cites W2412927822 @default.
• W2951598154 cites W2418574673 @default.
• W2951598154 cites W2429014501 @default.
• W2951598154 cites W2513715080 @default.
• W2951598154 cites W2566335889 @default.
• W2951598154 cites W2591039357 @default.
• W2951598154 cites W2891285073 @default.
• W2951598154 cites W4211038282 @default.
• W2951598154 cites W617327526 @default.
• W2951598154 doi "https://doi.org/10.1177/1971400919857544" @default.
• W2951598154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6856999" @default.
• W2951598154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31215319" @default.
• W2951598154 hasPublicationYear "2019" @default.

• next