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- W2951616516 abstract "ObesityWhether and how the gut microbiome impacts adipose tissue homeostasis is an open question. Virtue et al. showed that a high-fat diet in mice led to the activation of miR-181 in white adipose tissue (WAT). This in turn led to obesity, insulin resistance, and WAT inflammation. The increased expression of this microRNA was linked to a reduction in circulating microbiota-derived metabolites produced by tryptophan metabolism in the gut. In the plasma of obese humans, miR-181 expression was increased in WAT and indole was reduced, suggesting potential medical relevance for this axis.Sci. Transl. Med. 11 , eaav1892 (2019)." @default.
- W2951616516 created "2019-06-27" @default.
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- W2951616516 date "2019-06-13" @default.
- W2951616516 modified "2023-09-24" @default.
- W2951616516 title "A gut-fat axis" @default.
- W2951616516 doi "https://doi.org/10.1126/science.364.6445.1043-i" @default.
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