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• W2951622182 abstract "Various 2,3-substituted γ-butyrolactones have been synthesized by three-component reaction of aryl bromides, dimethyl itaconate and carbonyl compounds. The in vitro cytotoxic activity of these products was evaluated against a representative panel of cancer cell lines (KB, HCT116, MCF7, MCF7R, PC3, SK-OV3, HL60 and HL60R). One compound (4x) displays a good anti-proliferative activity with IC50 in the sub-micromolar range. The mechanism of action has been investigated using flow cytometry." @default.
• W2951622182 created "2019-06-27" @default.
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• W2951622182 date "2015-01-01" @default.
• W2951622182 modified "2023-09-30" @default.
• W2951622182 title "Synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents" @default.
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• W2951622182 doi "https://doi.org/10.1016/j.ejmech.2014.10.074" @default.
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