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• W2951639897 endingPage "211" @default.
• W2951639897 startingPage "187" @default.
• W2951639897 abstract "Abstract Centrosomes are important mediators of mitotic spindle assembly, and loss of centrosomes can lead to mitotic errors and cell death; however, it is also clear that cells can compensate for centrosome loss through multiple mechanisms... Centrosomes play a critical role in mitotic spindle assembly through their role in microtubule nucleation and bipolar spindle assembly. Loss of centrosomes can impair the ability of some cells to properly conduct mitotic division, leading to chromosomal instability, cell stress, and aneuploidy. Multiple aspects of the cellular response to mitotic error associated with centrosome loss appear to involve activation of JNK signaling. To further characterize the transcriptional effects of centrosome loss, we compared gene expression profiles of wild-type and acentrosomal cells from Drosophila wing imaginal discs. We found elevation of expression of JNK target genes, which we verified at the protein level. Consistent with this, the upregulated gene set showed significant enrichment for the AP-1 consensus DNA-binding sequence. We also found significant elevation in expression of genes regulating redox balance. Based on those findings, we examined oxidative stress after centrosome loss, revealing that acentrosomal wing cells have significant increases in reactive oxygen species (ROS). We then performed a candidate genetic screen and found that one of the genes upregulated in acentrosomal cells, glucose-6-phosphate dehydrogenase, plays an important role in buffering acentrosomal cells against increased ROS and helps protect those cells from cell death. Our data and other recent studies have revealed a complex network of signaling pathways, transcriptional programs, and cellular processes that epithelial cells use to respond to stressors, like mitotic errors, to help limit cell damage and maintain normal tissue development." @default.
• W2951639897 created "2019-06-27" @default.
• W2951639897 creator A5002078834 @default.
• W2951639897 creator A5068906620 @default.
• W2951639897 creator A5077356959 @default.
• W2951639897 date "2019-03-13" @default.
• W2951639897 modified "2023-10-16" @default.
• W2951639897 title "Centrosome Loss Triggers a Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress" @default.
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