FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951644416> ?p ?o ?g. }

• W2951644416 endingPage "463" @default.
• W2951644416 startingPage "449" @default.
• W2951644416 abstract "Transcriptional regulatory networks (TRNs) provide insight into cellular behavior by describing interactions between transcription factors (TFs) and their gene targets. The assay for transposase-accessible chromatin (ATAC)-seq, coupled with TF motif analysis, provides indirect evidence of chromatin binding for hundreds of TFs genome-wide. Here, we propose methods for TRN inference in a mammalian setting, using ATAC-seq data to improve gene expression modeling. We test our methods in the context of T Helper Cell Type 17 (Th17) differentiation, generating new ATAC-seq data to complement existing Th17 genomic resources. In this resource-rich mammalian setting, our extensive benchmarking provides quantitative, genome-scale evaluation of TRN inference, combining ATAC-seq and RNA-seq data. We refine and extend our previous Th17 TRN, using our new TRN inference methods to integrate all Th17 data (gene expression, ATAC-seq, TF knockouts, and ChIP-seq). We highlight newly discovered roles for individual TFs and groups of TFs (TF-TF modules) in Th17 gene regulation. Given the popularity of ATAC-seq, which provides high-resolution with low sample input requirements, we anticipate that our methods will improve TRN inference in new mammalian systems, especially in vivo, for cells directly from humans and animal models." @default.
• W2951644416 created "2019-06-27" @default.
• W2951644416 creator A5002268742 @default.
• W2951644416 creator A5002955503 @default.
• W2951644416 creator A5003912538 @default.
• W2951644416 creator A5004690085 @default.
• W2951644416 creator A5016829794 @default.
• W2951644416 creator A5044776929 @default.
• W2951644416 creator A5052109073 @default.
• W2951644416 creator A5055203249 @default.
• W2951644416 creator A5059321330 @default.
• W2951644416 creator A5060798225 @default.
• W2951644416 creator A5066176983 @default.
• W2951644416 creator A5069805624 @default.
• W2951644416 date "2019-01-29" @default.
• W2951644416 modified "2023-10-17" @default.
• W2951644416 title "Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells" @default.
• W2951644416 cites W1527927437 @default.
• W2951644416 cites W1602702667 @default.
• W2951644416 cites W1864161604 @default.
• W2951644416 cites W1958249906 @default.
• W2951644416 cites W1963522244 @default.
• W2951644416 cites W1967840109 @default.
• W2951644416 cites W1971133904 @default.
• W2951644416 cites W1977099733 @default.
• W2951644416 cites W1987320425 @default.
• W2951644416 cites W1993418188 @default.
• W2951644416 cites W1993616346 @default.
• W2951644416 cites W1995031758 @default.
• W2951644416 cites W2005530496 @default.
• W2951644416 cites W2009868429 @default.
• W2951644416 cites W2010457001 @default.
• W2951644416 cites W2010502047 @default.
• W2951644416 cites W2011680474 @default.
• W2951644416 cites W2013620058 @default.
• W2951644416 cites W2015416439 @default.
• W2951644416 cites W2021340905 @default.
• W2951644416 cites W2022110934 @default.
• W2951644416 cites W2026690931 @default.
• W2951644416 cites W2031792869 @default.
• W2951644416 cites W2033169664 @default.
• W2951644416 cites W2035099738 @default.
• W2951644416 cites W2042392223 @default.
• W2951644416 cites W2046749021 @default.
• W2951644416 cites W2058487327 @default.
• W2951644416 cites W2059699217 @default.
• W2951644416 cites W2061674320 @default.
• W2951644416 cites W2066203385 @default.
• W2951644416 cites W2069645361 @default.
• W2951644416 cites W2070171027 @default.
• W2951644416 cites W2071843884 @default.
• W2951644416 cites W2078621117 @default.
• W2951644416 cites W2081212776 @default.
• W2951644416 cites W2081370753 @default.
• W2951644416 cites W2083246774 @default.
• W2951644416 cites W2090037139 @default.
• W2951644416 cites W2092390808 @default.
• W2951644416 cites W2093009550 @default.
• W2951644416 cites W2102158172 @default.
• W2951644416 cites W2102619694 @default.
• W2951644416 cites W2103600875 @default.
• W2951644416 cites W2105924780 @default.
• W2951644416 cites W2108234281 @default.
• W2951644416 cites W2109384743 @default.
• W2951644416 cites W2110503722 @default.
• W2951644416 cites W2112237268 @default.
• W2951644416 cites W2112484474 @default.
• W2951644416 cites W2117757143 @default.
• W2951644416 cites W2125238755 @default.
• W2951644416 cites W2126602684 @default.
• W2951644416 cites W2129265801 @default.
• W2951644416 cites W2134526812 @default.
• W2951644416 cites W2134957137 @default.
• W2951644416 cites W2135553161 @default.
• W2951644416 cites W2138891173 @default.
• W2951644416 cites W2140952049 @default.
• W2951644416 cites W2142410561 @default.
• W2951644416 cites W2152121035 @default.
• W2951644416 cites W2152941516 @default.
• W2951644416 cites W2153453282 @default.
• W2951644416 cites W2154915765 @default.
• W2951644416 cites W2154951784 @default.
• W2951644416 cites W2155163918 @default.
• W2951644416 cites W2159482845 @default.
• W2951644416 cites W2163702333 @default.
• W2951644416 cites W2164298117 @default.
• W2951644416 cites W2169456326 @default.
• W2951644416 cites W2170551349 @default.
• W2951644416 cites W2178240050 @default.
• W2951644416 cites W2179438025 @default.
• W2951644416 cites W2210295781 @default.
• W2951644416 cites W2215197314 @default.
• W2951644416 cites W2253802357 @default.
• W2951644416 cites W2272703292 @default.
• W2951644416 cites W2296661036 @default.
• W2951644416 cites W2336438115 @default.
• W2951644416 cites W2403934794 @default.
• W2951644416 cites W2470513050 @default.

• next