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• W2951649191 endingPage "4080" @default.
• W2951649191 startingPage "4071" @default.
• W2951649191 abstract "This study was conducted to discover the effectiveness of dietary peptides (γ-[Glu](n=1,2)-Phe/-Met/-Val) as stimulators of cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretion. The kokumi-active γ-[Glu](n=1,2)-Phe/-Met/-Val at concentrations of 2.5-10 mM would trigger the release of CCK and GLP-1 by activating the calcium-sensing receptor (CaSR). The CaSR-mediated Ca2+/CaM/CaMK pathway was proposed in γ-[Glu](n=1,2)-Phe/-Met/-Val-induced CCK and GLP-1 secretion based on the following results: the exposure to γ-Glu-Phe increased the protein expression level (western blot analysis), the intracellular calcium ([Ca2+]i) mobilization in response to γ-[Glu](n=1,2)-Phe/-Met/-Val was strongly enhanced, and the inhibitors of signaling pathway proteins (NPS-2143, BAPTA-AM, and KN62) abolished partially γ-[Glu](n=1,2)-Phe/-Met/-Val-induced CCK and GLP-1 secretion." @default.
• W2951649191 created "2019-06-27" @default.
• W2951649191 creator A5007849150 @default.
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• W2951649191 date "2019-01-01" @default.
• W2951649191 modified "2023-10-16" @default.
• W2951649191 title "γ-[Glu]_(n=1,2)-Phe/-Met/-Val stimulates gastrointestinal hormone (CCK and GLP-1) secretion by activating the calcium-sensing receptor" @default.
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• W2951649191 doi "https://doi.org/10.1039/c9fo00313d" @default.
• W2951649191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31225563" @default.
• W2951649191 hasPublicationYear "2019" @default.
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