FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951666765> ?p ?o ?g. }

• W2951666765 endingPage "e1007075" @default.
• W2951666765 startingPage "e1007075" @default.
• W2951666765 abstract "For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the genetic background and rearing environment. The degree to which these factors influence related alleles, genes, or pathways similarly, and whether similar developmental mechanisms underlie variation in the expressivity of a single allele across conditions and among alleles is poorly understood. Besides their fundamental biological significance, these questions have important implications for the interpretation of functional genetic analyses, for example, if these factors alter the ordering of allelic series or patterns of complementation. We examined the impact of genetic background and rearing environment for a series of mutations spanning the range of phenotypic effects for both the scalloped and vestigial genes, which influence wing development in Drosophila melanogaster. Genetic background and rearing environment influenced the phenotypic outcome of mutations, including intra-genic interactions, particularly for mutations of moderate expressivity. We examined whether cellular correlates (such as cell proliferation during development) of these phenotypic effects matched the observed phenotypic outcome. While cell proliferation decreased with mutations of increasingly severe effects, surprisingly it did not co-vary strongly with the degree of background dependence. We discuss these findings and propose a phenomenological model to aid in understanding the biology of genes, and how this influences our interpretation of allelic effects in genetic analysis." @default.
• W2951666765 created "2019-06-27" @default.
• W2951666765 creator A5003130711 @default.
• W2951666765 creator A5003373358 @default.
• W2951666765 creator A5005124754 @default.
• W2951666765 creator A5020215107 @default.
• W2951666765 creator A5027622782 @default.
• W2951666765 creator A5029522857 @default.
• W2951666765 creator A5033474880 @default.
• W2951666765 creator A5046543329 @default.
• W2951666765 creator A5047132799 @default.
• W2951666765 creator A5051757273 @default.
• W2951666765 creator A5057614274 @default.
• W2951666765 creator A5062467083 @default.
• W2951666765 creator A5062727431 @default.
• W2951666765 creator A5066834170 @default.
• W2951666765 creator A5068913982 @default.
• W2951666765 creator A5075653251 @default.
• W2951666765 creator A5078243469 @default.
• W2951666765 date "2017-11-22" @default.
• W2951666765 modified "2023-10-12" @default.
• W2951666765 title "How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects" @default.
• W2951666765 cites W1534101457 @default.
• W2951666765 cites W1555879451 @default.
• W2951666765 cites W170125945 @default.
• W2951666765 cites W1803466717 @default.
• W2951666765 cites W1863647524 @default.
• W2951666765 cites W1866472634 @default.
• W2951666765 cites W1918050351 @default.
• W2951666765 cites W1951614488 @default.
• W2951666765 cites W1960622425 @default.
• W2951666765 cites W1966676631 @default.
• W2951666765 cites W1969088797 @default.
• W2951666765 cites W1975880030 @default.
• W2951666765 cites W2000507914 @default.
• W2951666765 cites W2000578376 @default.
• W2951666765 cites W2001348829 @default.
• W2951666765 cites W2004278293 @default.
• W2951666765 cites W2006149421 @default.
• W2951666765 cites W2022829940 @default.
• W2951666765 cites W2029918259 @default.
• W2951666765 cites W2031366681 @default.
• W2951666765 cites W2035903978 @default.
• W2951666765 cites W2037654695 @default.
• W2951666765 cites W2048513931 @default.
• W2951666765 cites W2050208964 @default.
• W2951666765 cites W2062623239 @default.
• W2951666765 cites W2064113953 @default.
• W2951666765 cites W2070475467 @default.
• W2951666765 cites W2071017660 @default.
• W2951666765 cites W2073818552 @default.
• W2951666765 cites W2074245141 @default.
• W2951666765 cites W2078121886 @default.
• W2951666765 cites W2078639868 @default.
• W2951666765 cites W2082797903 @default.
• W2951666765 cites W2091362324 @default.
• W2951666765 cites W2094232568 @default.
• W2951666765 cites W2095766417 @default.
• W2951666765 cites W2105671842 @default.
• W2951666765 cites W2106962907 @default.
• W2951666765 cites W2109317994 @default.
• W2951666765 cites W2112257928 @default.
• W2951666765 cites W2116367731 @default.
• W2951666765 cites W2117925179 @default.
• W2951666765 cites W2119948064 @default.
• W2951666765 cites W2120782923 @default.
• W2951666765 cites W2120999642 @default.
• W2951666765 cites W2121600028 @default.
• W2951666765 cites W2124821411 @default.
• W2951666765 cites W2125204556 @default.
• W2951666765 cites W2126690485 @default.
• W2951666765 cites W2128523604 @default.
• W2951666765 cites W2129901956 @default.
• W2951666765 cites W2135776750 @default.
• W2951666765 cites W2135933358 @default.
• W2951666765 cites W2142867950 @default.
• W2951666765 cites W2151385152 @default.
• W2951666765 cites W2159703561 @default.
• W2951666765 cites W2161597083 @default.
• W2951666765 cites W2162761901 @default.
• W2951666765 cites W2176186541 @default.
• W2951666765 cites W2199824220 @default.
• W2951666765 cites W2223919059 @default.
• W2951666765 cites W2258515607 @default.
• W2951666765 cites W2326628181 @default.
• W2951666765 cites W4235854794 @default.
• W2951666765 doi "https://doi.org/10.1371/journal.pgen.1007075" @default.
• W2951666765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5718557" @default.
• W2951666765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29166655" @default.
• W2951666765 hasPublicationYear "2017" @default.
• W2951666765 type Work @default.
• W2951666765 sameAs 2951666765 @default.
• W2951666765 citedByCount "45" @default.
• W2951666765 countsByYear W29516667652018 @default.
• W2951666765 countsByYear W29516667652019 @default.
• W2951666765 countsByYear W29516667652020 @default.
• W2951666765 countsByYear W29516667652021 @default.
• W2951666765 countsByYear W29516667652022 @default.

• next