FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951677908> ?p ?o ?g. }

• W2951677908 endingPage "4998" @default.
• W2951677908 startingPage "4987" @default.
• W2951677908 abstract "The synthesis and examination of two unique classes of duocarmycin SA analogs are described which we refer to as reversed and sandwiched analogs. Their examination established both the origin of the DNA alkylation selectivity and that both enantiomers of this class of natural products are subject to the same polynucleotide recognition features. The most beautiful demonstration of this is the complete switch in the enantiomeric alkylation selectivity of the reversed analogs which is only consistent with the noncovalent binding model and incompatible with alkylation site models of the origin of the DNA alkylation selectivity. In addition, dramatic alterations in the rates of DNA alkylation were observed among the agents and correlate with the presence or absence of an extended, rigid N2 amide substituent. This has led to the proposal of a previously unrecognized source of catalysis for the DNA alkylation reaction which was introduced in the preceding paper of this issue (J. Am. Chem. Soc. 1997, 119, 4977−4986)." @default.
• W2951677908 created "2019-06-27" @default.
• W2951677908 creator A5021080831 @default.
• W2951677908 creator A5030990841 @default.
• W2951677908 creator A5037746003 @default.
• W2951677908 creator A5049235255 @default.
• W2951677908 creator A5060234241 @default.
• W2951677908 creator A5062978929 @default.
• W2951677908 creator A5067745328 @default.
• W2951677908 creator A5070353893 @default.
• W2951677908 creator A5071532499 @default.
• W2951677908 date "1997-05-01" @default.
• W2951677908 modified "2023-10-03" @default.
• W2951677908 title "Reversed and Sandwiched Analogs of Duocarmycin SA: Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into the Source of Catalysis" @default.
• W2951677908 cites W1964669517 @default.
• W2951677908 cites W1965480599 @default.
• W2951677908 cites W1967421270 @default.
• W2951677908 cites W1974827970 @default.
• W2951677908 cites W1976190681 @default.
• W2951677908 cites W1979923851 @default.
• W2951677908 cites W1990494069 @default.
• W2951677908 cites W1991659350 @default.
• W2951677908 cites W2002097360 @default.
• W2951677908 cites W2003014984 @default.
• W2951677908 cites W2007342946 @default.
• W2951677908 cites W2030964931 @default.
• W2951677908 cites W2038231986 @default.
• W2951677908 cites W2048668515 @default.
• W2951677908 cites W2050067079 @default.
• W2951677908 cites W2066250630 @default.
• W2951677908 cites W2070831472 @default.
• W2951677908 cites W2078565719 @default.
• W2951677908 cites W2138061104 @default.
• W2951677908 cites W2142302030 @default.
• W2951677908 cites W2951713390 @default.
• W2951677908 doi "https://doi.org/10.1021/ja9637210" @default.
• W2951677908 hasPublicationYear "1997" @default.
• W2951677908 type Work @default.
• W2951677908 sameAs 2951677908 @default.
• W2951677908 citedByCount "63" @default.
• W2951677908 countsByYear W29516779082012 @default.
• W2951677908 countsByYear W29516779082013 @default.
• W2951677908 countsByYear W29516779082015 @default.
• W2951677908 countsByYear W29516779082016 @default.
• W2951677908 countsByYear W29516779082017 @default.
• W2951677908 countsByYear W29516779082018 @default.
• W2951677908 countsByYear W29516779082019 @default.
• W2951677908 countsByYear W29516779082021 @default.
• W2951677908 crossrefType "journal-article" @default.
• W2951677908 hasAuthorship W2951677908A5021080831 @default.
• W2951677908 hasAuthorship W2951677908A5030990841 @default.
• W2951677908 hasAuthorship W2951677908A5037746003 @default.
• W2951677908 hasAuthorship W2951677908A5049235255 @default.
• W2951677908 hasAuthorship W2951677908A5060234241 @default.
• W2951677908 hasAuthorship W2951677908A5062978929 @default.
• W2951677908 hasAuthorship W2951677908A5067745328 @default.
• W2951677908 hasAuthorship W2951677908A5070353893 @default.
• W2951677908 hasAuthorship W2951677908A5071532499 @default.
• W2951677908 hasConcept C118792377 @default.
• W2951677908 hasConcept C161790260 @default.
• W2951677908 hasConcept C164361826 @default.
• W2951677908 hasConcept C178790620 @default.
• W2951677908 hasConcept C185592680 @default.
• W2951677908 hasConcept C21951064 @default.
• W2951677908 hasConcept C2778689049 @default.
• W2951677908 hasConcept C486523 @default.
• W2951677908 hasConcept C552990157 @default.
• W2951677908 hasConcept C55493867 @default.
• W2951677908 hasConcept C71240020 @default.
• W2951677908 hasConceptScore W2951677908C118792377 @default.
• W2951677908 hasConceptScore W2951677908C161790260 @default.
• W2951677908 hasConceptScore W2951677908C164361826 @default.
• W2951677908 hasConceptScore W2951677908C178790620 @default.
• W2951677908 hasConceptScore W2951677908C185592680 @default.
• W2951677908 hasConceptScore W2951677908C21951064 @default.
• W2951677908 hasConceptScore W2951677908C2778689049 @default.
• W2951677908 hasConceptScore W2951677908C486523 @default.
• W2951677908 hasConceptScore W2951677908C552990157 @default.
• W2951677908 hasConceptScore W2951677908C55493867 @default.
• W2951677908 hasConceptScore W2951677908C71240020 @default.
• W2951677908 hasIssue "21" @default.
• W2951677908 hasLocation W29516779081 @default.
• W2951677908 hasOpenAccess W2951677908 @default.
• W2951677908 hasPrimaryLocation W29516779081 @default.
• W2951677908 hasRelatedWork W175101248 @default.
• W2951677908 hasRelatedWork W1966274406 @default.
• W2951677908 hasRelatedWork W1973052178 @default.
• W2951677908 hasRelatedWork W1989692008 @default.
• W2951677908 hasRelatedWork W2128093567 @default.
• W2951677908 hasRelatedWork W2382442675 @default.
• W2951677908 hasRelatedWork W2951305430 @default.
• W2951677908 hasRelatedWork W2953298349 @default.
• W2951677908 hasRelatedWork W3005527239 @default.
• W2951677908 hasRelatedWork W3007446011 @default.
• W2951677908 hasVolume "119" @default.
• W2951677908 isParatext "false" @default.
• W2951677908 isRetracted "false" @default.
• W2951677908 magId "2951677908" @default.

• next