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• W2951695536 abstract "Abstract In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the central nervous system. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs. The MOC-IHC synapse, functional from postnatal day (P)0 to hearing onset (P12), undergoes dramatic changes in the sensitivity to acetylcholine (ACh) and in the expression of key postsynaptic proteins. To evaluate whether there are associated changes in the properties of ACh release during this period, we used a cochlear preparation from mice at P4, P6-7 and P9-11 and monitored transmitter release from MOC terminals in voltage-clamped IHCs in the whole-cell configuration. The quantum content increased 5.6x from P4 to P9-11 due to increases in the size and replenishment rate of the readily releasable pool (RRP) of synaptic vesicles, without changes in their probability of release (P vesicle ) or quantum size. This strengthening in transmission was accompanied by changes in the short-term plasticity (STP) properties, which switched from facilitation at P4 to depression at P9-11. We have previously shown that at P9-11, ACh release is supported by P/Q and N-type voltage-gated calcium channels (VGCCs) and negatively regulated by BK potassium channels activated by Ca 2+ influx through L-type VGCCs. We now show that at P4 and P6-7, release is mediated by P/Q-, R- and L-type VGCCs. Interestingly, L-type VGCCs have a dual role: they both support release and fuel BK channels, suggesting that at immature stages the presynaptic proteins involved in release are less compartmentalized. Significance statement During postnatal development prior to the onset of hearing, cochlear IHCs present spontaneous Ca 2+ action potentials which release glutamate at the first auditory synapse in the absence of sound stimulation. The IHC Ca 2+ action potential frequency pattern, which is crucial for the correct establishment and function of the auditory system, is regulated by the efferent MOC system that transiently innervates IHCs during this period. We show short-term synaptic plasticity properties of the MOC-IHC synapse that tightly shape this critical developmental period." @default.
• W2951695536 created "2019-06-27" @default.
• W2951695536 creator A5028142872 @default.
• W2951695536 creator A5042777083 @default.
• W2951695536 creator A5049693917 @default.
• W2951695536 creator A5068838016 @default.
• W2951695536 creator A5083187195 @default.
• W2951695536 creator A5091877247 @default.
• W2951695536 date "2018-10-24" @default.
• W2951695536 modified "2023-10-06" @default.
• W2951695536 title "Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse" @default.
• W2951695536 cites W112825235 @default.
• W2951695536 cites W1553390829 @default.
• W2951695536 cites W1555733423 @default.
• W2951695536 cites W1574839934 @default.
• W2951695536 cites W1604744466 @default.
• W2951695536 cites W1606945552 @default.
• W2951695536 cites W1607388492 @default.
• W2951695536 cites W1750331652 @default.
• W2951695536 cites W1803630514 @default.
• W2951695536 cites W1877594537 @default.
• W2951695536 cites W1920274077 @default.
• W2951695536 cites W1955716838 @default.
• W2951695536 cites W1968019678 @default.
• W2951695536 cites W1968254921 @default.
• W2951695536 cites W1975727393 @default.
• W2951695536 cites W1975923329 @default.
• W2951695536 cites W1979801213 @default.
• W2951695536 cites W1985004569 @default.
• W2951695536 cites W1986047863 @default.
• W2951695536 cites W1989660560 @default.
• W2951695536 cites W1991145802 @default.
• W2951695536 cites W1991890788 @default.
• W2951695536 cites W1996899563 @default.
• W2951695536 cites W1998242611 @default.
• W2951695536 cites W1999772445 @default.
• W2951695536 cites W2002150079 @default.
• W2951695536 cites W2004343359 @default.
• W2951695536 cites W2009984517 @default.
• W2951695536 cites W2010346620 @default.
• W2951695536 cites W2010905290 @default.
• W2951695536 cites W2011057572 @default.
• W2951695536 cites W2012482374 @default.
• W2951695536 cites W2014514014 @default.
• W2951695536 cites W2017982454 @default.
• W2951695536 cites W2021608570 @default.
• W2951695536 cites W2022743067 @default.
• W2951695536 cites W2023130165 @default.
• W2951695536 cites W2028789389 @default.
• W2951695536 cites W2031821392 @default.
• W2951695536 cites W2044500873 @default.
• W2951695536 cites W2046491231 @default.
• W2951695536 cites W2049942136 @default.
• W2951695536 cites W2050935148 @default.
• W2951695536 cites W2051023125 @default.
• W2951695536 cites W2051428235 @default.
• W2951695536 cites W2051995905 @default.
• W2951695536 cites W2059093744 @default.
• W2951695536 cites W2061569848 @default.
• W2951695536 cites W2068673344 @default.
• W2951695536 cites W2068778243 @default.
• W2951695536 cites W2073188416 @default.
• W2951695536 cites W2073547426 @default.
• W2951695536 cites W2082135412 @default.
• W2951695536 cites W2082386266 @default.
• W2951695536 cites W2082549936 @default.
• W2951695536 cites W2082562281 @default.
• W2951695536 cites W2089424629 @default.
• W2951695536 cites W2090548559 @default.
• W2951695536 cites W2090662268 @default.
• W2951695536 cites W2096701787 @default.
• W2951695536 cites W2098692484 @default.
• W2951695536 cites W2106081526 @default.
• W2951695536 cites W2107226097 @default.
• W2951695536 cites W2107674902 @default.
• W2951695536 cites W2112927743 @default.
• W2951695536 cites W2115030010 @default.
• W2951695536 cites W2116895182 @default.
• W2951695536 cites W2119397841 @default.
• W2951695536 cites W2125211821 @default.
• W2951695536 cites W2125752525 @default.
• W2951695536 cites W2125877971 @default.
• W2951695536 cites W2137325594 @default.
• W2951695536 cites W2137626982 @default.
• W2951695536 cites W2138973416 @default.
• W2951695536 cites W2143842176 @default.
• W2951695536 cites W2147285542 @default.
• W2951695536 cites W2147381068 @default.
• W2951695536 cites W2150983664 @default.
• W2951695536 cites W2151526807 @default.
• W2951695536 cites W2158561409 @default.
• W2951695536 cites W2169344023 @default.
• W2951695536 cites W2170787296 @default.
• W2951695536 cites W2588156913 @default.
• W2951695536 cites W2610396255 @default.
• W2951695536 cites W2626318818 @default.
• W2951695536 cites W2789944208 @default.
• W2951695536 cites W2791142945 @default.
• W2951695536 cites W2799558871 @default.
• W2951695536 cites W373421631 @default.

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