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• W2951702307 endingPage "9009" @default.
• W2951702307 startingPage "9001" @default.
• W2951702307 abstract "The development of botanical materials as therapeutic agents involves the meticulous assessment of safety, efficacy, and quality. Compared with small-molecule drugs, quality control of botanical drugs confronts with more significant challenges due to their inherent complexity. Current quality control methods for botanical drugs, either prevailing chemical tests or emerging biological assays, are not able to meet recent demands of multiplexing, sensitivity, and speed. Here, we propose an on-demand strategy based on a direct analysis in real time-mass spectrometry (DART-MS) platform, which is capable of simultaneously analyzing multiple constituents and bioactivities of botanical drugs. Notably, the bioactivities are assessed by a multiple-enzyme assay that adopts cleavable mass spectrometry probes as enzymatic substrates: these probes labeled with a piperazine tag make possible sensitive, multiplexed, and quantitative enzyme activity measurements. The concept is successfully demonstrated via a case study of Danshen (Salvia miltiorrhiza) Injection where simultaneous detection of 34 constituents and inhibitory activities on two target enzymes can be achieved in just minutes. This proof-of-concept application also gives evidence that combining MS-sensitive probes with DART-MS can provide an environmentally friendly, highly sensitive analytical approach for botanical quality control." @default.
• W2951702307 created "2019-06-27" @default.
• W2951702307 creator A5001532729 @default.
• W2951702307 creator A5060415810 @default.
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• W2951702307 date "2019-06-17" @default.
• W2951702307 modified "2023-10-18" @default.
• W2951702307 title "Mass Spectrometry-Sensitive Probes Coupled with Direct Analysis in Real Time for Simultaneous Sensing of Chemical and Biological Properties of Botanical Drugs" @default.
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• W2951702307 doi "https://doi.org/10.1021/acs.analchem.9b01251" @default.
• W2951702307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31246426" @default.
• W2951702307 hasPublicationYear "2019" @default.
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