Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951704461> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2951704461 endingPage "no" @default.
- W2951704461 startingPage "no" @default.
- W2951704461 abstract "4-Aryl-3-methyl-4-oxobutane-1,1,2,2-tetracarbonitriles reacted with morpholine to give 8-amino-3aryl-1-imino-4-methyl-6-(morpholin-4-yl)-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles. Ar = Ph (a), 4-ClC6H4 (b), 4-MeC6H4 (c). 4-Oxoalkane-1,1,2,2-tetracarbonitriles are extensively studied representatives of the series of polynitrile compounds. Derivatives of 4-oxoalkane-1,1,2,2tetracarbonitriles are known as potential antitumor agents [1] and coordination polymers with interesting topology [2]. We now perform extensive studies on the transformations of 4-oxoalkane-1,1,2,2-tetracarbonitriles by the action of nitrogen-centered nucleophiles [3]. 4-Oxoalkane-1,1,2,2-tetracarbonitriles were reported to react with ammonia and amines to form 3-amino-7oxo-4,6-diazabicyclo[3.2.1]oct-2-ene-1,2-dicarbonitriles [4], 3-amidinio-2-aminopyridine-4-carboxylates [5], diethylammonium 3,4-dicyano-5,6,7,8-tetrahydroquinolin-2-olates [6], and ammonium 4-aryl-4oxo-1,1,2-tricyanobut-2-en-1-ides [7]. We recently showed that the reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with morpholine leads to 5-amino-2(morpholin-4-yl)-3H-pyrrole-3,4-dicarbonitriles [8, 9] and found that nitrogen-centered nucleophiles preferably add to the β-cyano groups of polyelectrophilic tetranitriles. The resulting compounds are representatives of a poorly explored class of aza heterocycles, 3H-pyrroles, which may be regarded as nitrogen-containing cyclopentadiene analogs. Despite limited published data, some 3H-pyrroles were found to exhibit antimicrobial and antitumor activity [10–12]. With a view to synthesize new functionally substituted 3H-pyrrole derivatives, we extended the series of 4-oxoalkane-1,1,2,2-tetracarbonitrile substrates and examined their reaction with morpholine in more detail. The reactions of 4-aryl-3-methyl-4-oxobutane-1,1,2,2DOI: 10.1134/S1070428013060110" @default.
- W2951704461 created "2019-06-27" @default.
- W2951704461 creator A5013482504 @default.
- W2951704461 creator A5024556999 @default.
- W2951704461 creator A5025539901 @default.
- W2951704461 creator A5029124883 @default.
- W2951704461 creator A5055588768 @default.
- W2951704461 date "2013-12-02" @default.
- W2951704461 modified "2023-09-27" @default.
- W2951704461 title "ChemInform Abstract: Spiro Heterocyclization of 4-Aryl-4-oxobutane-1,1,2,2-tetracarbonitriles to 3H-Pyrrole Derivatives, 2-Oxa-7-azaspiro[4.4]nona-3,6,8-trienes." @default.
- W2951704461 cites W2062280930 @default.
- W2951704461 doi "https://doi.org/10.1002/chin.201351116" @default.
- W2951704461 hasPublicationYear "2013" @default.
- W2951704461 type Work @default.
- W2951704461 sameAs 2951704461 @default.
- W2951704461 citedByCount "0" @default.
- W2951704461 crossrefType "journal-article" @default.
- W2951704461 hasAuthorship W2951704461A5013482504 @default.
- W2951704461 hasAuthorship W2951704461A5024556999 @default.
- W2951704461 hasAuthorship W2951704461A5025539901 @default.
- W2951704461 hasAuthorship W2951704461A5029124883 @default.
- W2951704461 hasAuthorship W2951704461A5055588768 @default.
- W2951704461 hasConcept C155647269 @default.
- W2951704461 hasConcept C161790260 @default.
- W2951704461 hasConcept C178790620 @default.
- W2951704461 hasConcept C178907741 @default.
- W2951704461 hasConcept C185592680 @default.
- W2951704461 hasConcept C2776382133 @default.
- W2951704461 hasConcept C2779400197 @default.
- W2951704461 hasConcept C2780263894 @default.
- W2951704461 hasConcept C2781056017 @default.
- W2951704461 hasConcept C2781076698 @default.
- W2951704461 hasConcept C537208039 @default.
- W2951704461 hasConcept C71240020 @default.
- W2951704461 hasConceptScore W2951704461C155647269 @default.
- W2951704461 hasConceptScore W2951704461C161790260 @default.
- W2951704461 hasConceptScore W2951704461C178790620 @default.
- W2951704461 hasConceptScore W2951704461C178907741 @default.
- W2951704461 hasConceptScore W2951704461C185592680 @default.
- W2951704461 hasConceptScore W2951704461C2776382133 @default.
- W2951704461 hasConceptScore W2951704461C2779400197 @default.
- W2951704461 hasConceptScore W2951704461C2780263894 @default.
- W2951704461 hasConceptScore W2951704461C2781056017 @default.
- W2951704461 hasConceptScore W2951704461C2781076698 @default.
- W2951704461 hasConceptScore W2951704461C537208039 @default.
- W2951704461 hasConceptScore W2951704461C71240020 @default.
- W2951704461 hasIssue "51" @default.
- W2951704461 hasLocation W29517044611 @default.
- W2951704461 hasOpenAccess W2951704461 @default.
- W2951704461 hasPrimaryLocation W29517044611 @default.
- W2951704461 hasVolume "44" @default.
- W2951704461 isParatext "false" @default.
- W2951704461 isRetracted "false" @default.
- W2951704461 magId "2951704461" @default.
- W2951704461 workType "article" @default.