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• W2951715242 startingPage "6306" @default.
• W2951715242 abstract "Background: Many pathways regarding healthy cells and/or linked to diseases onset and progression depend on large assemblies including multi-protein complexes. Protein-protein interactions may occur through a vast array of modules known as protein interaction domains (PIDs). Objective: This review concerns with PIDs recognizing post-translationally modified peptide sequences and intends to provide the scientific community with state of art knowledge on their 3D structures, binding topologies and potential applications in the drug discovery field. Method: Several databases, such as the Pfam (Protein family), the SMART (Simple Modular Architecture Research Tool) and the PDB (Protein Data Bank), were searched to look for different domain families and gain structural information on protein complexes in which particular PIDs are involved. Recent literature on PIDs and related drug discovery campaigns was retrieved through Pubmed and analyzed. Results and Conclusion: PIDs are rather versatile as concerning their binding preferences. Many of them recognize specifically only determined amino acid stretches with post-translational modifications, a few others are able to interact with several post-translationally modified sequences or with unmodified ones. Many PIDs can be linked to different diseases including cancer. The tremendous amount of available structural data led to the structure-based design of several molecules targeting protein-protein interactions mediated by PIDs, including peptides, peptidomimetics and small compounds. More studies are needed to fully role out, among different families, PIDs that can be considered reliable therapeutic targets, however, attacking PIDs rather than catalytic domains of a particular protein may represent a route to obtain selective inhibitors." @default.
• W2951715242 created "2019-06-27" @default.
• W2951715242 creator A5038213943 @default.
• W2951715242 creator A5066912496 @default.
• W2951715242 creator A5082896813 @default.
• W2951715242 date "2020-11-06" @default.
• W2951715242 modified "2023-09-27" @default.
• W2951715242 title "Protein Interaction Domains and Post-Translational Modifications: Structural Features and Drug Discovery Applications" @default.
• W2951715242 cites W1242375680 @default.
• W2951715242 cites W1509466986 @default.
• W2951715242 cites W1512133948 @default.
• W2951715242 cites W1548344349 @default.
• W2951715242 cites W1620967969 @default.
• W2951715242 cites W1814445630 @default.
• W2951715242 cites W1965445778 @default.
• W2951715242 cites W1967657108 @default.
• W2951715242 cites W1968174732 @default.
• W2951715242 cites W1969288514 @default.
• W2951715242 cites W1971364991 @default.
• W2951715242 cites W1971673692 @default.
• W2951715242 cites W197294569 @default.
• W2951715242 cites W1976962550 @default.
• W2951715242 cites W1978221294 @default.
• W2951715242 cites W1978262131 @default.
• W2951715242 cites W1982186905 @default.
• W2951715242 cites W1982750125 @default.
• W2951715242 cites W1982791788 @default.
• W2951715242 cites W1985694585 @default.
• W2951715242 cites W1986407289 @default.
• W2951715242 cites W1988852424 @default.
• W2951715242 cites W1988876415 @default.
• W2951715242 cites W1989232733 @default.
• W2951715242 cites W1991103421 @default.
• W2951715242 cites W1994344724 @default.
• W2951715242 cites W1996412713 @default.
• W2951715242 cites W2000192731 @default.
• W2951715242 cites W2000204195 @default.
• W2951715242 cites W2001130216 @default.
• W2951715242 cites W2001762032 @default.
• W2951715242 cites W2002533513 @default.
• W2951715242 cites W2003632864 @default.
• W2951715242 cites W2003872705 @default.
• W2951715242 cites W2004271888 @default.
• W2951715242 cites W2004653335 @default.
• W2951715242 cites W2005593816 @default.
• W2951715242 cites W2006957104 @default.
• W2951715242 cites W2007767755 @default.
• W2951715242 cites W2009339798 @default.
• W2951715242 cites W2009467084 @default.
• W2951715242 cites W2010255232 @default.
• W2951715242 cites W2011043571 @default.
• W2951715242 cites W2012317303 @default.
• W2951715242 cites W2012399428 @default.
• W2951715242 cites W2013921059 @default.
• W2951715242 cites W2015961921 @default.
• W2951715242 cites W2016311817 @default.
• W2951715242 cites W2018276268 @default.
• W2951715242 cites W2019078000 @default.
• W2951715242 cites W2019623269 @default.
• W2951715242 cites W2020004235 @default.
• W2951715242 cites W2020050973 @default.
• W2951715242 cites W2020242791 @default.
• W2951715242 cites W2021945943 @default.
• W2951715242 cites W2022095303 @default.
• W2951715242 cites W2022480984 @default.
• W2951715242 cites W2024342992 @default.
• W2951715242 cites W2026081838 @default.
• W2951715242 cites W2026271132 @default.
• W2951715242 cites W2029675956 @default.
• W2951715242 cites W2031580512 @default.
• W2951715242 cites W2031615571 @default.
• W2951715242 cites W2033406586 @default.
• W2951715242 cites W2033440882 @default.
• W2951715242 cites W2034195376 @default.
• W2951715242 cites W2034619626 @default.
• W2951715242 cites W2036158314 @default.
• W2951715242 cites W2036472425 @default.
• W2951715242 cites W2038254973 @default.
• W2951715242 cites W2039920298 @default.
• W2951715242 cites W2040031153 @default.
• W2951715242 cites W2043148368 @default.
• W2951715242 cites W2043186621 @default.
• W2951715242 cites W2048551141 @default.
• W2951715242 cites W2049463639 @default.
• W2951715242 cites W2051025707 @default.
• W2951715242 cites W2051152566 @default.
• W2951715242 cites W2051247910 @default.
• W2951715242 cites W2051693520 @default.
• W2951715242 cites W2051758765 @default.
• W2951715242 cites W2052138090 @default.
• W2951715242 cites W2053218283 @default.
• W2951715242 cites W2054466658 @default.
• W2951715242 cites W2054808650 @default.
• W2951715242 cites W2054883096 @default.
• W2951715242 cites W2055354487 @default.
• W2951715242 cites W2057805290 @default.
• W2951715242 cites W2059059097 @default.
• W2951715242 cites W2060224804 @default.

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