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- W2951738275 abstract "Several neurodegeneration (N) metrics using structural MRI are used for the purpose of Alzheimer's disease (AD)-related staging, including hippocampal volume, global atrophy, and an AD signature composite consisting of thickness or volumetric estimates derived from regions impacted early in AD. This study sought to determine if less user-intensive estimates of global atrophy and hippocampal volume were equivalent to a thickness-based AD signature from FreeSurfer for defining N across the AD continuum (i.e., individuals who are amyloid-positive (A+)).Cognitively unimpaired (CU) late middle-aged and older adults, as well as A+ mild cognitive impairment (MCI) and A+ AD dementia individuals, with available CSF and structural MRI scan <1.5 years apart, were selected for the study (n = 325, mean age = 62). First, in a subsample of A+ AD dementia and matched biomarker-negative (i.e., A- and tau tangle pathology (T)-) CU controls (n = 40), we examined ROC characteristics and identified N cut-offs using Youden's J for neurofilament light chain protein (NfL) and each of three MRI-based measures: a thickness-based AD signature from FreeSurfer, hippocampal volume (using FIRST), and a simple estimate of global atrophy (the ratio of intracranial CSF segmented volume to brain tissue volume, using SPM12). Based on the results from the ROC analyses, we then examined the concordance between NfL N positivity and N positivity for each MRI-based metric using Cohen's Kappa in the remaining subsample of 285 individuals. Finally, in the full sample (n = 325), we examined the relationship between the four measures of N and group membership across the AD continuum using Kruskal-Wallis tests and Cliff's deltas.The three MRI-based metrics and CSF NfL similarly discriminated between the A-T- CU (n = 20) and A+ AD (n = 20) groups (AUCs ≥0.885; ps < 0.001). Using the cut-off values derived from the ROCs to define N positivity, there was weak concordance between NfL and all three MRI-derived metrics of N in the subsample of 285 individuals (Cohen's Kappas ≤0.429). Finally, the three MRI-based measures of N and CSF NfL showed similar associations with AD continuum group (i.e., Kruskal-Wallis ps < 0.001), with relatively larger effect sizes noted when comparing the A-T- CU to the A+ MCI (Cliff's deltas ≥0.741) and A+ AD groups (Cliff's deltas ≥0.810) than to the A+T- CU (Cliff's deltas = 0.112-0.298) and A + T+ CU groups (Cliff's deltas = 0.212-0.731).These findings suggest that the three MRI-based morphometric estimates and CSF NfL similarly differentiate individuals across the AD continuum on N status. In many applications, a simple estimate of global atrophy may be preferred as an MRI marker of N across the AD continuum given its methodological robustness and ease of calculation when compared to hippocampal volume or a cortical thickness AD signature." @default.
- W2951738275 created "2019-06-27" @default.
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- W2951738275 date "2019-01-01" @default.
- W2951738275 modified "2023-10-14" @default.
- W2951738275 title "Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum" @default.
- W2951738275 cites W1919825598 @default.
- W2951738275 cites W1934117767 @default.
- W2951738275 cites W1964472291 @default.
- W2951738275 cites W1972978214 @default.
- W2951738275 cites W1973110960 @default.
- W2951738275 cites W1975879668 @default.
- W2951738275 cites W1978684823 @default.
- W2951738275 cites W1978813754 @default.
- W2951738275 cites W1978832801 @default.
- W2951738275 cites W1980842500 @default.
- W2951738275 cites W1991952617 @default.
- W2951738275 cites W1994329769 @default.
- W2951738275 cites W2004293194 @default.
- W2951738275 cites W2028845695 @default.
- W2951738275 cites W2036162736 @default.
- W2951738275 cites W2038003677 @default.
- W2951738275 cites W2040423869 @default.
- W2951738275 cites W2049943618 @default.
- W2951738275 cites W2059104398 @default.
- W2951738275 cites W2061699647 @default.
- W2951738275 cites W2079708060 @default.
- W2951738275 cites W2083307175 @default.
- W2951738275 cites W2088129757 @default.
- W2951738275 cites W2089940272 @default.
- W2951738275 cites W2096742242 @default.
- W2951738275 cites W2101135654 @default.
- W2951738275 cites W2102508963 @default.
- W2951738275 cites W2102961599 @default.
- W2951738275 cites W2106753219 @default.
- W2951738275 cites W2108944087 @default.
- W2951738275 cites W2111951761 @default.
- W2951738275 cites W2112010296 @default.
- W2951738275 cites W2112518510 @default.
- W2951738275 cites W2114222094 @default.
- W2951738275 cites W2115017507 @default.
- W2951738275 cites W2115281122 @default.
- W2951738275 cites W2125043543 @default.
- W2951738275 cites W2133652987 @default.
- W2951738275 cites W2134547791 @default.
- W2951738275 cites W2136343476 @default.
- W2951738275 cites W2142950794 @default.
- W2951738275 cites W2147597108 @default.
- W2951738275 cites W2161737267 @default.
- W2951738275 cites W2187760945 @default.
- W2951738275 cites W2321587642 @default.
- W2951738275 cites W2327547544 @default.
- W2951738275 cites W2460653397 @default.
- W2951738275 cites W2469997639 @default.
- W2951738275 cites W2473313434 @default.
- W2951738275 cites W2582524520 @default.
- W2951738275 cites W2608642452 @default.
- W2951738275 cites W2612655633 @default.
- W2951738275 cites W2766003287 @default.
- W2951738275 cites W2766030065 @default.
- W2951738275 cites W2766242262 @default.
- W2951738275 cites W2769941316 @default.
- W2951738275 cites W2790169598 @default.
- W2951738275 cites W2798054687 @default.
- W2951738275 cites W2887375324 @default.
- W2951738275 cites W2888277947 @default.
- W2951738275 cites W2891079125 @default.
- W2951738275 cites W2921985330 @default.
- W2951738275 cites W2950459061 @default.
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- W2951738275 doi "https://doi.org/10.1016/j.nicl.2019.101895" @default.
- W2951738275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599872" @default.
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