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- W2951746380 abstract "Isoxazolo[4,5-d]pyridazin-4(5H) [and 7(6H)]-ones can be respectively synthesised in a one-pot two-step synthetic sequence from 4 or 3-arylsulfinyl-5-alkoxyfuran-2(5H)-ones, involving their reactions with nitrile oxides and subsequent reflux with hydrazine hydrate into a 4:3 mixture of water/acetic acid. The 1,3-dipolar reaction takes place with complete regioselectivity, which is controlled by the position of the sulfinyl group at the dipolarophile, yielding, after desulfinylation and subsequent opening of the lactone ring, the two possible regioisomeric 3-substituted isoxazoles bearing formyl and carboxylic acid moieties at C-4 and C-5. These compounds, as well as their methyl esters, can be independently transformed into the corresponding isoxazolopyridazinones in high yields by reaction with hydrazine hydrate." @default.
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- W2951746380 date "2002-01-01" @default.
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- W2951746380 title "A New Entry to Isoxazolo[4,5-d]pyridazin-4(5H) [and 7(6H)]-ones from Functionalized Vinyl Sulfoxides" @default.
- W2951746380 doi "https://doi.org/10.1055/s-2002-19334" @default.
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