FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951780564> ?p ?o ?g. }

• W2951780564 endingPage "296" @default.
• W2951780564 startingPage "285" @default.
• W2951780564 abstract "In vitro experiments have proved that Fibroblast Growth Factor 9 (FGF9) was decreased in Schwann cells (SCs) in which Wallerian degeneration (WD) occurred after nerve injury. We hypothesize that FGF9 downregulation in WD has some biological influence on Schwann cells (SCs) and macrophages – the two most important cell components involved in WD. In this study, we employed strategies to regulate FGF9 in sciatic nerve crush by generating a mouse model, wherein Fgf9 was specifically knocked-out in SCs, and an intraneural injection of human FGF9 protein administered to overexpress FGF9 independently. Furthermore, an inhibitor of extracellular-regulated kinases 1/2 (ERK1/2), PD0325901, was used to clarify the underlying downstream mechanism of ERK1/2 activated by FGF9. Analysis of WD revealed the novel features of FGF9: (i) FGF9 was widely expressed in axons and SCs, and was decreased during WD process. (ii) Fgf9 knockout in SCs impaired the debris clearance and eventually impeded the regeneration of nerve fibers after damage. (iii) Fgf9 knockout in SCs promoted the dedifferentiation of SCs and delayed the infiltration of macrophages by decreasing Mcp1, Tnfα, Il1β levels and leaky blood-nerve-barrier (BNB) in WD. (iv) FGF9 injection preserved the nerve fibers, inhibited SCs dedifferentiation and accelerated macrophages infiltration. (v) ERK1/2 phosphorylation was increased by exogenous FGF9 injection. P75, Cyclin D1, Mcp1, Tnfα, Il1β, c-Jun changes by FGF9 intraneural injection were partially reversed by the ERK1/2 inhibitor. Conclusion was that FGF9 inhibited the dedifferentiation of SCs and accelerated the accumulation of macrophages in WD, and exogenous FGF9 took effects partially by ERK1/2." @default.
• W2951780564 created "2019-06-27" @default.
• W2951780564 creator A5001392284 @default.
• W2951780564 creator A5011645644 @default.
• W2951780564 creator A5016380761 @default.
• W2951780564 creator A5022967729 @default.
• W2951780564 creator A5026274455 @default.
• W2951780564 creator A5036674320 @default.
• W2951780564 creator A5048114341 @default.
• W2951780564 creator A5056788729 @default.
• W2951780564 creator A5060305340 @default.
• W2951780564 creator A5091499047 @default.
• W2951780564 date "2019-10-01" @default.
• W2951780564 modified "2023-10-16" @default.
• W2951780564 title "FGF9 alters the Wallerian degeneration process by inhibiting Schwann cell transformation and accelerating macrophage infiltration" @default.
• W2951780564 cites W119704665 @default.
• W2951780564 cites W1784352764 @default.
• W2951780564 cites W1857061736 @default.
• W2951780564 cites W1960355435 @default.
• W2951780564 cites W1965358479 @default.
• W2951780564 cites W1965571714 @default.
• W2951780564 cites W1965932992 @default.
• W2951780564 cites W1980469138 @default.
• W2951780564 cites W1983673947 @default.
• W2951780564 cites W1985611350 @default.
• W2951780564 cites W1986292249 @default.
• W2951780564 cites W1993737194 @default.
• W2951780564 cites W1995717532 @default.
• W2951780564 cites W2000521581 @default.
• W2951780564 cites W2005067021 @default.
• W2951780564 cites W2077902472 @default.
• W2951780564 cites W2079782815 @default.
• W2951780564 cites W2085384084 @default.
• W2951780564 cites W2085585614 @default.
• W2951780564 cites W2092137682 @default.
• W2951780564 cites W2099320079 @default.
• W2951780564 cites W2116356198 @default.
• W2951780564 cites W2122259704 @default.
• W2951780564 cites W2122813537 @default.
• W2951780564 cites W2136722399 @default.
• W2951780564 cites W2141030054 @default.
• W2951780564 cites W2142077499 @default.
• W2951780564 cites W2142490204 @default.
• W2951780564 cites W2146236251 @default.
• W2951780564 cites W2151516954 @default.
• W2951780564 cites W2168389928 @default.
• W2951780564 cites W2178578592 @default.
• W2951780564 cites W2262612887 @default.
• W2951780564 cites W2333893582 @default.
• W2951780564 cites W2466362243 @default.
• W2951780564 cites W2483493672 @default.
• W2951780564 cites W2810621856 @default.
• W2951780564 cites W4213263913 @default.
• W2951780564 doi "https://doi.org/10.1016/j.brainresbull.2019.06.011" @default.
• W2951780564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31220553" @default.
• W2951780564 hasPublicationYear "2019" @default.
• W2951780564 type Work @default.
• W2951780564 sameAs 2951780564 @default.
• W2951780564 citedByCount "9" @default.
• W2951780564 countsByYear W29517805642020 @default.
• W2951780564 countsByYear W29517805642021 @default.
• W2951780564 countsByYear W29517805642022 @default.
• W2951780564 countsByYear W29517805642023 @default.
• W2951780564 crossrefType "journal-article" @default.
• W2951780564 hasAuthorship W2951780564A5001392284 @default.
• W2951780564 hasAuthorship W2951780564A5011645644 @default.
• W2951780564 hasAuthorship W2951780564A5016380761 @default.
• W2951780564 hasAuthorship W2951780564A5022967729 @default.
• W2951780564 hasAuthorship W2951780564A5026274455 @default.
• W2951780564 hasAuthorship W2951780564A5036674320 @default.
• W2951780564 hasAuthorship W2951780564A5048114341 @default.
• W2951780564 hasAuthorship W2951780564A5056788729 @default.
• W2951780564 hasAuthorship W2951780564A5060305340 @default.
• W2951780564 hasAuthorship W2951780564A5091499047 @default.
• W2951780564 hasConcept C105702510 @default.
• W2951780564 hasConcept C170493617 @default.
• W2951780564 hasConcept C185592680 @default.
• W2951780564 hasConcept C2777004073 @default.
• W2951780564 hasConcept C2780862704 @default.
• W2951780564 hasConcept C2781149210 @default.
• W2951780564 hasConcept C55493867 @default.
• W2951780564 hasConcept C74373430 @default.
• W2951780564 hasConcept C77390185 @default.
• W2951780564 hasConcept C86803240 @default.
• W2951780564 hasConcept C95444343 @default.
• W2951780564 hasConceptScore W2951780564C105702510 @default.
• W2951780564 hasConceptScore W2951780564C170493617 @default.
• W2951780564 hasConceptScore W2951780564C185592680 @default.
• W2951780564 hasConceptScore W2951780564C2777004073 @default.
• W2951780564 hasConceptScore W2951780564C2780862704 @default.
• W2951780564 hasConceptScore W2951780564C2781149210 @default.
• W2951780564 hasConceptScore W2951780564C55493867 @default.
• W2951780564 hasConceptScore W2951780564C74373430 @default.
• W2951780564 hasConceptScore W2951780564C77390185 @default.
• W2951780564 hasConceptScore W2951780564C86803240 @default.
• W2951780564 hasConceptScore W2951780564C95444343 @default.
• W2951780564 hasFunder F4320321001 @default.
• W2951780564 hasLocation W29517805641 @default.

• next