FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951793230> ?p ?o ?g. }

• W2951793230 endingPage "e3512" @default.
• W2951793230 startingPage "e3512" @default.
• W2951793230 abstract "Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases containing three domains: an extracellular receptor domain, a single transmembrane helix, and an intracellular tyrosine kinase domain. FGFRs are activated by fibroblast growth factors (FGFs) as part of complex signal transduction cascades regulating angiogenesis, skeletal formation, cell differentiation, proliferation, cell survival, and cancer. We have developed the first recombinant expression system in E. coli to produce a construct of human FGFR2 containing its transmembrane and extracellular receptor domains. We demonstrate that the expressed construct is functional in binding heparin and dimerizing. Size exclusion chromatography demonstrates that the purified FGFR2 does not form a complex with FGF1 or adopts an inactive dimer conformation. Progress towards the successful recombinant production of intact FGFRs will facilitate further biochemical experiments and structure determination that will provide insight into how extracellular FGF binding activates intracellular kinase activity." @default.
• W2951793230 created "2019-06-27" @default.
• W2951793230 creator A5045998722 @default.
• W2951793230 creator A5086812348 @default.
• W2951793230 date "2017-06-29" @default.
• W2951793230 modified "2023-10-01" @default.
• W2951793230 title "Recombinant expression in E. coli of human FGFR2 with its transmembrane and extracellular domains" @default.
• W2951793230 cites W1977937474 @default.
• W2951793230 cites W1988476050 @default.
• W2951793230 cites W1994105285 @default.
• W2951793230 cites W1997336183 @default.
• W2951793230 cites W1999882817 @default.
• W2951793230 cites W2025547755 @default.
• W2951793230 cites W2027770279 @default.
• W2951793230 cites W2028415754 @default.
• W2951793230 cites W2030155901 @default.
• W2951793230 cites W2031049200 @default.
• W2951793230 cites W2046786765 @default.
• W2951793230 cites W2069676076 @default.
• W2951793230 cites W2088388211 @default.
• W2951793230 cites W2097152121 @default.
• W2951793230 cites W2098466520 @default.
• W2951793230 cites W2100100451 @default.
• W2951793230 cites W2102098049 @default.
• W2951793230 cites W2103128020 @default.
• W2951793230 cites W2103806208 @default.
• W2951793230 cites W2106465830 @default.
• W2951793230 cites W2106510392 @default.
• W2951793230 cites W2121880361 @default.
• W2951793230 cites W2122965729 @default.
• W2951793230 cites W2125096800 @default.
• W2951793230 cites W2135734220 @default.
• W2951793230 cites W2138820253 @default.
• W2951793230 cites W2149594557 @default.
• W2951793230 cites W2156655664 @default.
• W2951793230 cites W2169147580 @default.
• W2951793230 cites W2239128674 @default.
• W2951793230 cites W61536043 @default.
• W2951793230 cites W817910744 @default.
• W2951793230 doi "https://doi.org/10.7717/peerj.3512" @default.
• W2951793230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5493969" @default.
• W2951793230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28674664" @default.
• W2951793230 hasPublicationYear "2017" @default.
• W2951793230 type Work @default.
• W2951793230 sameAs 2951793230 @default.
• W2951793230 citedByCount "2" @default.
• W2951793230 countsByYear W29517932302018 @default.
• W2951793230 countsByYear W29517932302021 @default.
• W2951793230 crossrefType "journal-article" @default.
• W2951793230 hasAuthorship W2951793230A5045998722 @default.
• W2951793230 hasAuthorship W2951793230A5086812348 @default.
• W2951793230 hasBestOaLocation W29517932301 @default.
• W2951793230 hasConcept C101544691 @default.
• W2951793230 hasConcept C104317684 @default.
• W2951793230 hasConcept C118892022 @default.
• W2951793230 hasConcept C143065580 @default.
• W2951793230 hasConcept C147708747 @default.
• W2951793230 hasConcept C170493617 @default.
• W2951793230 hasConcept C191709040 @default.
• W2951793230 hasConcept C24530287 @default.
• W2951793230 hasConcept C28406088 @default.
• W2951793230 hasConcept C32619005 @default.
• W2951793230 hasConcept C42362537 @default.
• W2951793230 hasConcept C49418065 @default.
• W2951793230 hasConcept C50044444 @default.
• W2951793230 hasConcept C55493867 @default.
• W2951793230 hasConcept C62478195 @default.
• W2951793230 hasConcept C74373430 @default.
• W2951793230 hasConcept C82867764 @default.
• W2951793230 hasConcept C86803240 @default.
• W2951793230 hasConcept C95444343 @default.
• W2951793230 hasConceptScore W2951793230C101544691 @default.
• W2951793230 hasConceptScore W2951793230C104317684 @default.
• W2951793230 hasConceptScore W2951793230C118892022 @default.
• W2951793230 hasConceptScore W2951793230C143065580 @default.
• W2951793230 hasConceptScore W2951793230C147708747 @default.
• W2951793230 hasConceptScore W2951793230C170493617 @default.
• W2951793230 hasConceptScore W2951793230C191709040 @default.
• W2951793230 hasConceptScore W2951793230C24530287 @default.
• W2951793230 hasConceptScore W2951793230C28406088 @default.
• W2951793230 hasConceptScore W2951793230C32619005 @default.
• W2951793230 hasConceptScore W2951793230C42362537 @default.
• W2951793230 hasConceptScore W2951793230C49418065 @default.
• W2951793230 hasConceptScore W2951793230C50044444 @default.
• W2951793230 hasConceptScore W2951793230C55493867 @default.
• W2951793230 hasConceptScore W2951793230C62478195 @default.
• W2951793230 hasConceptScore W2951793230C74373430 @default.
• W2951793230 hasConceptScore W2951793230C82867764 @default.
• W2951793230 hasConceptScore W2951793230C86803240 @default.
• W2951793230 hasConceptScore W2951793230C95444343 @default.
• W2951793230 hasLocation W29517932301 @default.
• W2951793230 hasLocation W29517932302 @default.
• W2951793230 hasLocation W29517932303 @default.
• W2951793230 hasLocation W29517932304 @default.
• W2951793230 hasOpenAccess W2951793230 @default.
• W2951793230 hasPrimaryLocation W29517932301 @default.
• W2951793230 hasRelatedWork W1985595661 @default.
• W2951793230 hasRelatedWork W2003632139 @default.

• next