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• W2951799559 abstract "Abstract 3,4‐Dichloro‐2(5 H )‐furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4‐aryl‐3‐chloro‐2(5 H )‐furanones either by Suzuki‐ or Stille‐type reactions. These monochloro derivatives have been used as precursors either to ( Z )‐4‐aryl‐5‐[1‐(aryl)methylidene]‐3‐chloro‐2(5 H )‐furanones, including naturally occurring rubrolide M, or to unsymmetrical 3,4‐diaryl‐2(5 H )‐furanones. Some 2(5 H )‐furanone derivatives so prepared have been found to exhibit significant cytotoxic activity in vitro against the NCI three‐cell‐line panel, but limited cytotoxicity against the NCI human tumor 60 cell‐line panel. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)" @default.
• W2951799559 created "2019-06-27" @default.
• W2951799559 creator A5013136464 @default.
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• W2951799559 creator A5060503623 @default.
• W2951799559 date "2003-06-01" @default.
• W2951799559 modified "2023-10-07" @default.
• W2951799559 title "Mucochloric Acid: A Useful Synthon for the Selective Synthesis of 4‐Aryl‐3‐chloro‐2(5<i>H</i>)‐furanones, (<i>Z</i>)‐4‐Aryl‐5‐[1‐(aryl)methylidene]‐3‐chloro‐2(5<i>H</i>)‐furanones and 3,4‐Diaryl‐2(5<i>H</i>)‐furanones" @default.
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• W2951799559 doi "https://doi.org/10.1002/ejoc.200300097" @default.
• W2951799559 hasPublicationYear "2003" @default.
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