Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951806975> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2951806975 abstract "Given that leukocytes, derived from microvasculature, are critical for cervical ripening (CR) and that VEGF, whose levels increase near term, is the key architect of microvascular remodeling, VEGF likely plays vital roles in CR. However, its definite roles in CR are unknown. Here, we use VEGF siRNA and genome-wide DNA microarray analysis, to decipher VEGF-related genes in pregnant rat. We used a siRNA-generating plasmid DNAs targeting VEGF. 40 ug of siRNA, dissolved in Lipofectamine and mixed in a micellar nanocontainer polymer, pluronic block copolymer, were administered to the cervix intravaginally at days 17 and 19 of pregnancy, leading to a 50% reduction in VEGF at day 20, based on RT-PCR densitometric analysis. Moreover, analysis of microarray data, according to the EASE score, revealed that, not only the gene expression of “hallmark” biological processes of VEGF, such as cell proliferation and motility, circulation, tissues remodeling, heat shock protein activity and cell adhesion molecule activity were altered, but, intriguingly, also of unexpected, but important candidates involved in CR, most notably oxytocin and prostaglandins. These data are novel and important, in that they shed new insights in VEGF's possible roles and mechanisms in cervical events near term, including CR. Support: Appalachian St Univ & NEOUCOM grants." @default.
- W2951806975 created "2019-06-27" @default.
- W2951806975 creator A5007524033 @default.
- W2951806975 creator A5018111189 @default.
- W2951806975 creator A5021815159 @default.
- W2951806975 creator A5025305957 @default.
- W2951806975 creator A5044415887 @default.
- W2951806975 creator A5044875921 @default.
- W2951806975 creator A5070881087 @default.
- W2951806975 creator A5089076259 @default.
- W2951806975 date "2006-03-01" @default.
- W2951806975 modified "2023-10-14" @default.
- W2951806975 title "Genome‐wide delineation of VEGF‐related genes in the cervix of pregnant rats reveal unexpected candidates" @default.
- W2951806975 doi "https://doi.org/10.1096/fasebj.20.5.a1151" @default.
- W2951806975 hasPublicationYear "2006" @default.
- W2951806975 type Work @default.
- W2951806975 sameAs 2951806975 @default.
- W2951806975 citedByCount "0" @default.
- W2951806975 crossrefType "journal-article" @default.
- W2951806975 hasAuthorship W2951806975A5007524033 @default.
- W2951806975 hasAuthorship W2951806975A5018111189 @default.
- W2951806975 hasAuthorship W2951806975A5021815159 @default.
- W2951806975 hasAuthorship W2951806975A5025305957 @default.
- W2951806975 hasAuthorship W2951806975A5044415887 @default.
- W2951806975 hasAuthorship W2951806975A5044875921 @default.
- W2951806975 hasAuthorship W2951806975A5070881087 @default.
- W2951806975 hasAuthorship W2951806975A5089076259 @default.
- W2951806975 hasConcept C104317684 @default.
- W2951806975 hasConcept C121608353 @default.
- W2951806975 hasConcept C150194340 @default.
- W2951806975 hasConcept C167734588 @default.
- W2951806975 hasConcept C186836561 @default.
- W2951806975 hasConcept C2777740455 @default.
- W2951806975 hasConcept C40767141 @default.
- W2951806975 hasConcept C49923114 @default.
- W2951806975 hasConcept C502942594 @default.
- W2951806975 hasConcept C54355233 @default.
- W2951806975 hasConcept C8415881 @default.
- W2951806975 hasConcept C86803240 @default.
- W2951806975 hasConcept C92087593 @default.
- W2951806975 hasConcept C95444343 @default.
- W2951806975 hasConceptScore W2951806975C104317684 @default.
- W2951806975 hasConceptScore W2951806975C121608353 @default.
- W2951806975 hasConceptScore W2951806975C150194340 @default.
- W2951806975 hasConceptScore W2951806975C167734588 @default.
- W2951806975 hasConceptScore W2951806975C186836561 @default.
- W2951806975 hasConceptScore W2951806975C2777740455 @default.
- W2951806975 hasConceptScore W2951806975C40767141 @default.
- W2951806975 hasConceptScore W2951806975C49923114 @default.
- W2951806975 hasConceptScore W2951806975C502942594 @default.
- W2951806975 hasConceptScore W2951806975C54355233 @default.
- W2951806975 hasConceptScore W2951806975C8415881 @default.
- W2951806975 hasConceptScore W2951806975C86803240 @default.
- W2951806975 hasConceptScore W2951806975C92087593 @default.
- W2951806975 hasConceptScore W2951806975C95444343 @default.
- W2951806975 hasFunder F4320311475 @default.
- W2951806975 hasIssue "5" @default.
- W2951806975 hasLocation W29518069751 @default.
- W2951806975 hasOpenAccess W2951806975 @default.
- W2951806975 hasPrimaryLocation W29518069751 @default.
- W2951806975 hasRelatedWork W1983994322 @default.
- W2951806975 hasRelatedWork W2006024165 @default.
- W2951806975 hasRelatedWork W2053053668 @default.
- W2951806975 hasRelatedWork W2114409792 @default.
- W2951806975 hasRelatedWork W2362238002 @default.
- W2951806975 hasRelatedWork W2374855950 @default.
- W2951806975 hasRelatedWork W2415025170 @default.
- W2951806975 hasRelatedWork W2900947575 @default.
- W2951806975 hasRelatedWork W2998765584 @default.
- W2951806975 hasRelatedWork W74695042 @default.
- W2951806975 hasVolume "20" @default.
- W2951806975 isParatext "false" @default.
- W2951806975 isRetracted "false" @default.
- W2951806975 magId "2951806975" @default.
- W2951806975 workType "article" @default.