Matches in SemOpenAlex for { <https://semopenalex.org/work/W2951808650> ?p ?o ?g. }
- W2951808650 endingPage "614" @default.
- W2951808650 startingPage "603" @default.
- W2951808650 abstract "Sleep disturbances are common and a major source of disability in Parkinson's disease (PD). Primary and secondary insomnia, rapid eye movement sleep behavior disorder (RDB), central sleep apnea, restless legs, and nocturnal akinesia are common sleep disturbances in PD. Prodromal presence of RBD is associated with a more severe motor and non-motor PD subtype implying a significant disease-modifying effect of this parasomnia. Other disease-modifying mechanisms of sleep disturbances in PD include impaired glymphatic clearance, endoplasmic reticulum stress, nocturnal brain deoxygenation and inflammatory processes among others. Impairments of neural circuit switching and imbalance between inhibitory and excitatory neuronal populations are likely responsible for episodic sleep disturbances, in particular RBD. As neural circuits may predict patterns of α-synuclein propagation in the nervous system, impairments of such circuits are of high relevance for PD pathophysiology. Future research is needed to determine whether appropriate treatment for disturbed sleep might slow progression of PD." @default.
- W2951808650 created "2019-06-27" @default.
- W2951808650 creator A5014562669 @default.
- W2951808650 creator A5091086774 @default.
- W2951808650 date "2019-07-30" @default.
- W2951808650 modified "2023-10-17" @default.
- W2951808650 title "Sleep Disturbance as Potential Risk and Progression Factor for Parkinson’s Disease" @default.
- W2951808650 cites W1910961849 @default.
- W2951808650 cites W1968173634 @default.
- W2951808650 cites W1970018024 @default.
- W2951808650 cites W1974858585 @default.
- W2951808650 cites W1986783470 @default.
- W2951808650 cites W1990744953 @default.
- W2951808650 cites W1996955271 @default.
- W2951808650 cites W1998887601 @default.
- W2951808650 cites W2009706073 @default.
- W2951808650 cites W2014321132 @default.
- W2951808650 cites W2017946180 @default.
- W2951808650 cites W2026275665 @default.
- W2951808650 cites W2026783498 @default.
- W2951808650 cites W2027429673 @default.
- W2951808650 cites W2057147978 @default.
- W2951808650 cites W2071956191 @default.
- W2951808650 cites W2073449985 @default.
- W2951808650 cites W2073618557 @default.
- W2951808650 cites W2077161354 @default.
- W2951808650 cites W2081345769 @default.
- W2951808650 cites W2083153290 @default.
- W2951808650 cites W2097714090 @default.
- W2951808650 cites W2098260062 @default.
- W2951808650 cites W2100314515 @default.
- W2951808650 cites W2107015882 @default.
- W2951808650 cites W2110834613 @default.
- W2951808650 cites W2121300131 @default.
- W2951808650 cites W2124068164 @default.
- W2951808650 cites W2141052704 @default.
- W2951808650 cites W2141459724 @default.
- W2951808650 cites W2143790126 @default.
- W2951808650 cites W2146268820 @default.
- W2951808650 cites W2163225965 @default.
- W2951808650 cites W2166211493 @default.
- W2951808650 cites W2167183660 @default.
- W2951808650 cites W2412045403 @default.
- W2951808650 cites W2513283541 @default.
- W2951808650 cites W2519596987 @default.
- W2951808650 cites W2564565615 @default.
- W2951808650 cites W2587736287 @default.
- W2951808650 cites W2604233789 @default.
- W2951808650 cites W2610180795 @default.
- W2951808650 cites W2610801820 @default.
- W2951808650 cites W2767325420 @default.
- W2951808650 cites W2781096668 @default.
- W2951808650 cites W2803083570 @default.
- W2951808650 cites W2807772034 @default.
- W2951808650 cites W2884309857 @default.
- W2951808650 cites W2884714191 @default.
- W2951808650 cites W2890806217 @default.
- W2951808650 cites W2896917224 @default.
- W2951808650 cites W2902161130 @default.
- W2951808650 cites W2905123367 @default.
- W2951808650 cites W2910825225 @default.
- W2951808650 cites W2911993021 @default.
- W2951808650 cites W2912003143 @default.
- W2951808650 cites W2915377575 @default.
- W2951808650 cites W2917107887 @default.
- W2951808650 doi "https://doi.org/10.3233/jpd-191627" @default.
- W2951808650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6700634" @default.
- W2951808650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31227656" @default.
- W2951808650 hasPublicationYear "2019" @default.
- W2951808650 type Work @default.
- W2951808650 sameAs 2951808650 @default.
- W2951808650 citedByCount "63" @default.
- W2951808650 countsByYear W29518086502020 @default.
- W2951808650 countsByYear W29518086502021 @default.
- W2951808650 countsByYear W29518086502022 @default.
- W2951808650 countsByYear W29518086502023 @default.
- W2951808650 crossrefType "journal-article" @default.
- W2951808650 hasAuthorship W2951808650A5014562669 @default.
- W2951808650 hasAuthorship W2951808650A5091086774 @default.
- W2951808650 hasBestOaLocation W29518086501 @default.
- W2951808650 hasConcept C111919701 @default.
- W2951808650 hasConcept C118552586 @default.
- W2951808650 hasConcept C126322002 @default.
- W2951808650 hasConcept C1513209611 @default.
- W2951808650 hasConcept C151730666 @default.
- W2951808650 hasConcept C15744967 @default.
- W2951808650 hasConcept C169760540 @default.
- W2951808650 hasConcept C169900460 @default.
- W2951808650 hasConcept C2775841894 @default.
- W2951808650 hasConcept C2777601987 @default.
- W2951808650 hasConcept C2779134260 @default.
- W2951808650 hasConcept C2779734285 @default.
- W2951808650 hasConcept C41008148 @default.
- W2951808650 hasConcept C50440223 @default.
- W2951808650 hasConcept C71924100 @default.
- W2951808650 hasConcept C86803240 @default.
- W2951808650 hasConcept C99508421 @default.
- W2951808650 hasConceptScore W2951808650C111919701 @default.