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- W2951811716 abstract "Clinical Practice Points•Lung cancer is the leading cause of cancer-related death worldwide. Over 85% of lung cancers are classified as non–small-cell lung cancer (NSCLC), and identification of oncogenic alterations in subsets of patients with NSCLC is transforming clinical care. The majority of patients with NSCLC with an anaplastic lymphoma kinase (ALK) fusion respond well to ALK tyrosine kinase inhibitors (ALK-TKIs).•In this case report, we present a 52-year-old female nonsmoker carrying a WD (Trp-Asp) planar cell polarity (PCP) effector gene (WDPCP)-ALK fusion who was diagnosed with lung adenocarcinoma and initially responded to first-generation ALK-TKI but later developed disease progression in association with WDPCP-ALK and C1156Y.•The results suggest that WDPCP-ALK acts as an oncogenic driver. •Lung cancer is the leading cause of cancer-related death worldwide. Over 85% of lung cancers are classified as non–small-cell lung cancer (NSCLC), and identification of oncogenic alterations in subsets of patients with NSCLC is transforming clinical care. The majority of patients with NSCLC with an anaplastic lymphoma kinase (ALK) fusion respond well to ALK tyrosine kinase inhibitors (ALK-TKIs).•In this case report, we present a 52-year-old female nonsmoker carrying a WD (Trp-Asp) planar cell polarity (PCP) effector gene (WDPCP)-ALK fusion who was diagnosed with lung adenocarcinoma and initially responded to first-generation ALK-TKI but later developed disease progression in association with WDPCP-ALK and C1156Y.•The results suggest that WDPCP-ALK acts as an oncogenic driver." @default.
- W2951811716 created "2019-06-27" @default.
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- W2951811716 date "2019-09-01" @default.
- W2951811716 modified "2023-09-28" @default.
- W2951811716 title "Next-generation Sequencing Identified a Novel WDPCP-ALK Fusion Sensitive to Crizotinib in Lung Adenocarcinoma" @default.
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- W2951811716 doi "https://doi.org/10.1016/j.cllc.2019.06.001" @default.
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