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• W2951836191 abstract "Lithium salts have been in use for the treatment of bipolar disorder for more than 50 years, but their pharmacological mode of action remains a matter of conjecture. Li+ and Mg2+ share many physicochemical properties. Not surprisingly, many reported cellular targets for Li+ action involve Mg2+-activated enzymes, which are inhibited by Li+. In this Account, we describe results from our and other laboratories that suggest that a competition mechanism between Li+ and Mg2+ ions for Mg2+-binding sites in cellular components is the underlying theme in putative mechanisms of Li+ action." @default.
• W2951836191 created "2019-06-27" @default.
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• W2951836191 date "2006-03-11" @default.
• W2951836191 modified "2023-10-14" @default.
• W2951836191 title "Is Competition between Li⁺ and Mg²⁺ the Underlying Theme in the Proposed Mechanisms for the Pharmacological Action of Lithium Salts in Bipolar Disorder?" @default.
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• W2951836191 doi "https://doi.org/10.1021/ar030197a" @default.
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